Guest Interview with George Sellhorn of Flourish Labs (OR)

George Sellhorn Ph.D, is the founder, owner and Principal Scientist of Flourish Labs in Portland Oregon and earned his Ph.D. in Molecular Plant Sciences from Washington State University (2006) and his B.S. in Biology from Indiana University (1999). George has worked in both academia and the biotechnology industries from 2006-2021 working on projects such as HIV vaccine development, production, characterization and pre-clinical evaluation as well as bioconjugate-based therapeutics including pegylated interferon for multiple sclerosis, bifunctional antibodies and antibody drug conjugates for breast cancer and poly(carboxybetaine) L-asparaginase bioconjugates for acute lymphoblastic leukemia.George has 23 years of extensive experience with liquid chromatography using both High-Performance Liquid Chromatography (HPLC) and Fast protein liquid chromatography (FPLC) and these techniques are one of his primary expertise. Some of the leadership roles he has held in the laboratory include Senior Scientist, Laboratory Director and Principal Investigator. George has also worked in the medical and recreational Cannabis industries from 2009-2021 which included cultivation, processing and consulting in Washington, Oregon and Colorado. Flourish Labs, LLC was founded in August 2021 and opened its services to customers on January 1st , 2022.Link to George’s business here at Flourish Labs (OR): https://flourishlabsoregon.com/Glossary of termsAPE—Albino Penis Envy, considered one of the most potent strains of psilocybin cubensis in terms 4-ACO: Or O-acetylpsilocybin or 4-Aco-DMT: semi synthetic derivatives of psilocybin often used in pharmacologic studiesBOL or 2-Br-LSD. Non hallucinogenic LSD derivative synthesized by Albert Hofman (who also synthesized LSD). CLIA and CAP: College of American pathologists and Clinical Laboratory Improvement Amendments—regulatory bodies for clinical laboratories. COA-certificate of analysis, offered by third party product testing labs. CRM: Certified Reference Materials (not Customer Relationship Management in this context)Entourage effect: hypothesis that compounds in cannabis other than CBD and THC act in synergy to exhibit pharmacologic effect (pretty good evidence to support this). GPCR: G protein coupled receptor: largest family of membrane proteins LOQ—Limit of quantification LOD—Level of detection. Level of detection is smallest concentration of a sample that can be consistently analyzed with 95% probability, LOQ is smallest concentration that can be measured with less than 10 to 20% variation. PSK (Krestin): Also known as Polysaccharide K, derived from Coriolus versicolor mushroom, widely used as folk remedy and adjuvant therapy for cancer treatment in some cultures. Terpenoids: Broad class of naturally occurring 5 Carbon molecules that show wide range of pharmacologic activities. 5-ME-O-DMT: Psychoactive drug derived from toad venom of glands of the Sonoran Desert toad (lots more to come on this). Get full access to Neural Pharm at neuralpharm.substack.com/subscribe