Hormones, and Abdominal Pain 🧬🦠🔥 How Estrogen Amplifies Gut Sensitivity in Females

🧠🦠 Why does abdominal pain affect women more? Science offers a cellular answer.   A new Science study uncovers an estrogen-tuned gut pain circuit in which peptide YY–secreting enteroendocrine cells activate serotonin-releasing cells, sensitizing gut sensory nerves—especially in females. Hormones, microbes, and diet converge locally in the colon to amplify visceral pain, offering a biologically grounded explanation for menstrual-cycle variability and female-predominant disorders like irritable bowel syndrome.   📖 Venkataraman et al., Science (Dec 2025) Precision medicine begins by taking sex seriously.