How aerobic exercise fights alzheimer's in middle-aged adults. |Espresso Knowledge Shots

Alzheimer's disease is a growing public health concern, with no effective treatments currently available. Exercise has emerged as a promising lifestyle approach to maintain cognitive health and delay dementia onset. However, blood-based biomarkers are needed to evaluate how physical activity impacts the brain. Candidates like the myokine cathepsin B (CTSB), brain-derived neurotrophic factor (BDNF), anti-aging protein klotho, and metabolites related to cognition have been proposed as potential exercise biomarkers. A study titled “Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease” by Gaitán and colleagues published in Frontiers in Endocrinology in 2021 examined how an aerobic exercise program affected these systemic factors in middle-aged adults at increased genetic risk for Alzheimer’s disease. This randomized controlled trial conducted by Gaitán et al. provides insight into how regular physical activity could potentially help delay the onset of dementia. The study suggests some effects of exercise on systemic factors that may reflect beneficial changes in the brain. //~Social media~///: These episodes of 'Espresso Knowledge Shots' or quick paper reviews are also available on the 'Decoding Healthcare Research' Podcast. You can find it as 'Decoding Healthcare Research' on Spotify, Apple Podcasts, and Amazon Music. Enjoy! -Follow us on Instagram and TikTok @agora_health and on Facebook at Agora Health. -Find Dr. E.F.Rain as @dr.ef.rain on Instagram. Visit our website at agora-community.com, where you can access all our content and join our exclusive online community of healthcare professionals. It's the perfect place for networking, case discussions, conversations about our professional practice as healthcare professionals, and more! -Reference: Gaitán JM, Moon HY, Stremlau M, Dubal DB, Cook DB, Okonkwo OC, van Praag H. Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease. Front Endocrinol (Lausanne). 2021 May 20;12:660181. doi: 10.3389/fendo.2021.660181. PMID: 34093436; PMCID: PMC8173166.