How Alexander Berger weighs the world’s biggest problems

Coefficient Giving, one of the world’s largest effective-giving funders, is about to go even bigger.On the heels of its biggest funding year ever in 2025 — in which it channeled over $1 billion to highest-impact causes — the organization formerly known as Open Philanthropy and funded by Facebook cofounder Dustin Moskovitz and his wife Cari Tuna is eyeing annual growth upward of 50% and bringing on more staff to get it done.The person behind that vision is Alexander Berger, Coefficient Giving’s cofounder and CEO. Berger is in charge of turning Facebook wealth — and, increasingly, funds from other donors — into as many lives saved and improved as possible. The organization is a major funder in global health and development, catastrophic risk, research and innovation, and even farm animal welfare.Last week, Coefficient Giving launched a new pooled fund to tackle Group A Streptococcus — an easily treated disease that is still responsible for nearly 700,000 deaths a year — a cause that reflects the organization’s framework for tackling problems that are important, neglected, and tractable.In a rare, in-depth interview with Devex Senior Reporter Michael Igoe, Berger sheds light on Coefficient Giving’s rapid growth plans, its strategy for choosing high-impact causes, the rise of artificial intelligence philanthropy, and his own approach to affecting change in an uncertain world.This is the first episode of Theory of Change, a new podcast series from Devex featuring candid interviews with leaders shaping the future of global development.