How Ketones Boost Brain and Body Health | Dr Mark Mattson

Dr. Mark Madsen discusses the science behind intermittent fasting, ketosis, and their effects on health, aging, and brain function. He explores mechanisms like BDNF, autophagy, and evolutionary perspectives on stress responses.Key Topics- Mechanisms of fasting benefits: calorie restriction, glycation, inflammation- Role of ketones as signaling molecules and energy sources- BDNF and brain plasticity- Exogenous ketones and athletic performance- Evolutionary perspective on stress and adaptationChapters00:00 Introduction and guest introduction00:11 Ben's fasting experiments and Ori Hoffmeckler influence01:13 Are fasting benefits due to calorie restriction or other mechanisms?01:31 Experimental evidence on fasting and lifespan extension in mice02:30 Human study on 5-2 fasting and metabolic health05:27 Benefits of fasting beyond calorie restriction07:11 Fasting, ketosis, and athletic performance08:10 Second wind phenomenon and metabolic flexibility09:16 Fasting and metabolic health in athletes like Matthew Pinson10:25 Exogenous ketones and their role in health and performance16:02 BDNF, brain health, and the effects of ketones19:10 Evolutionary perspective on brain and body adaptation20:23 Stress response, autophagy, and cellular health25:47 Exercise, challenge, and brain resilience27:50 Lifestyle, obesity, and cognitive health28:34 The importance of stress and challenge in evolution43:31 Impact of media and public awareness on fasting science45:28 Clinical trials and health benefits of intermittent fasting46:26 Healthcare system, prevention, and societal challenges48:23 Barriers to healthy lifestyle and socioeconomic factors49:10 Diet, supplements, and natural chemicals in health53:22 Neuroendocrinology and brain development54:30 Neurotransmitters, glutamate, and neural wiring56:26 Excitotoxicity and neural damage in disease58:00 Dietary chemicals and adaptive stress response01:02:59 Evolutionary mechanisms of plant chemicals and human health01:04:58 Dose, duration, and frequency of stressors01:06:06 Optimal intermittent fasting patterns and research challenges01:07:41 Connecting lifestyle, stress, and evolutionary biologyMark Madsen's Institute - https://matsonianinstitute.orgBrain Ponderings Podcast - https://matsonianinstitute.org/podcastWebsite - https://matsonianinstitute.orgPodcast - https://matsonianinstitute.org/podcast-------------------------------------------------------------------------------------------------------------------------🌈 Exploring the benefits of red and infra light therapy? Our community receive 10% off the FlexBeam from Recharge Health via this link: ⬇️https://rechargehealthas.sjv.io/DyJ3mn (learn more about the benefits of healing with light in our 'Light as Medicine' Playlist).🤝 Join the community - by subscribing, you are self-selecting as a health nerd. We like you. We applaud you. You are shaping in real time the future of health information. As a thank you, we pledge to bring you the best we can, where we are, with the tools we have.🎧 Listen to us on-the-go! Available wherever you listen to your favourite podcasts. New episode every Wednesday! Hosted on Acast. See acast.com/privacy for more information.