EPISODE · Apr 25, 2026 · 15 MIN
How to Build a Baseline and Understand Your Risk
from Race Against Mind: An Alzheimer's Prevention Investigation · host Sarah Kuhn
For APOE4 carriers, knowing your risk is only useful if you know what to do with it. In this episode, Sarah walks through her path to developing a baseline, and discusses the labs that actually matter, fasting insulin, homocysteine, hs-CRP, Vitamin D etc. Sarah also discusses why standard functional medicine isn't specific enough for APOE4 biology, and how to interpret baseline data without losing your mind in the process.Whats in this episode: What APOE4 actually is, and what it isn'tWhy the "nothing you can do" frame is the most expensive mistake APOE4 carriers can makeThe research caveat problem: why so many studies don't apply to people like meHow I built my first baseline with blood work and cognitive testing before changing anythingWhy I started with Parsley Health and then moved to Dale Bredesen's PreCODE programWhat my PreCODE report revealed across metabolic, inflammatory, and cognitive domainsWhy my cognitive scores required more context than just a number on a page (ADHD, breastfeeding, medication status)Three practical takeaways for anyone at the beginning of this journeyWhy exercise leads Season 1, even though it wasn't where I startedShow Notes & References
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How to Build a Baseline and Understand Your Risk
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