EPISODE · Feb 20, 2026 · 7 MIN
How Weight Loss Medications Actually Work in Your Body
from Mindfully Integrative Show · host Dr. Damaris Grossmann FNP-C
Send us Fan MailWe break down the mechanism of action for GLP-1 receptor agonists like tirzepatide (Zepbound/Mounjaro) and semaglutide, explaining how these medications work in the body to regulate appetite and metabolism.• GLP-1 medications contain a C20 fatty diacid that binds to albumin, prolonging half-life• These drugs target both GIP and GLP-1 receptors to regulate appetite and caloric intake• Receptors are found in brain areas involved in appetite regulation and throughout the GI system• Pharmacodynamics include increased insulin sensitivity, reduced glucagon secretion, and delayed gastric emptying• Medications are absorbed subcutaneously with about 80% bioavailability • Distribution occurs throughout the body with 5-6 day half-life, explaining weekly dosing• Metabolism occurs primarily through the liver with excretion via urine• Common injection sites include arms, legs, stomach, or back (the "margarita" zones)Never do this on your own without real supervision. Everything has to be done safely, with a healthcare provider and someone that is aware of where you stand and how you are. Support the showSponsor Affiliates Empowering Your Healthhttps://www.atecam.com/Get YOUR Own Joburg Protein Snacks Discount Code: Damaris15 Or Damaris18Feeling need to Lose Weight & Become metabolically HealthyGET METABOLIC COURSE GLP 1 REseTThis course is designed for individuals looking to optimize their metabolic health through integrative and functional medicine approaches. Whether you're on a GLP-1 medication or seeking natural ways to enhance your metabolic function, this course provides actionable steps, expert insights, and a personalized roadmap sustainable wellness.Are you feeling stressed, tired, or Metabolism imbalanced? Take advantage of our free mindful steps to help improve your well-being.ENJOY ONE OF our Books Mindful Ways Health Wealth & Life https://stan.store/MindfullyintegrativeJoin Yearly membership ALL IN ONE FUNCTION HEALTHAsk Us for help with Medica...
What this episode covers
Send us Fan Mail We break down the mechanism of action for GLP-1 receptor agonists like tirzepatide (Zepbound/Mounjaro) and semaglutide, explaining how these medications work in the body to regulate appetite and metabolism. • GLP-1 medications contain a C20 fatty diacid that binds to albumin, prolonging half-life • These drugs target both GIP and GLP-1 receptors to regulate appetite and caloric intake • Receptors are found in brain areas involved in appetite regulation and throughout the GI ...
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How Weight Loss Medications Actually Work in Your Body
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