Hydrazaline

Trade – Apresoline Class – Vasodilator MOA – Directly dilates peripheral blood vessels Indication – HTN associated with preeclampsia and eclampsia, HTN crisis Contraindication – Patients taking diazoxide or MAOI’s, coronary artery disease, stroke, angina, dissecting aortic aneurism, mitral valve and rheumatic heart disease. Side effects – Headache, angina, flushing, palpitations, reflex tachycardia, anorexia, N/V, diarrhea, hypotension, syncope, peripheral vasodilation, peripheral edema, fluid retention, pareshesias. Dosing Preeclampsia and eclampsia: Adult : 5-10mg IV repeat every 20-30mins until Systolic pressure of 90-105mmhg Acute HTN ( not associated with preeclampsia ) Adult :10-20mg IV/IM Pedi : 1mo – 12yr 0.1-0.2 mg/kg IV/IM max 20mg per dose