Hydrocortisone

Trade – Cortef Class – Corticosteroid MOA – Reduces inflammation by multiple mechanisms. As a steroid it replaces the steroids that are lacking in adrenal insufficiency. Indications – Adrenal insufficiency, allergic reactions, anaphylaxis, asthma, COPD Contraindications – Cushing Syndrome, known sensitivity to benzyl alcohol, Use with caution in diabetes, HTN, CHF, known systemic fungal infection, renal disease, idiopathic thrombocytopenia, psychosis, seizure disorder, GI disease, glaucoma. Side effects – Leukocytosis, hyperglycemia, increased infection, decreased wound healing, increased rate of death from sepsis. Dosing Anaphylactic shock Adult 100-500mg IV,IO, or IM Pedi 2-10 mg/kg per day IV,IO, or IM max 500mg