Immune Aging with Natalia Mitin, PhD

Can You Measure Immune Aging? Natalia Mitin on Immune Resilience, Senescence, and Personalized LongevityIn this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Natalia Mitin, co-founder and CEO of Sapere Bio, to explore one of longevity medicine’s biggest blind spots: how do we measure immune function and immune aging in an individual—and use that information to make better decisions?From immune resilience, T-cell exhaustion, and cellular senescence to thymic regeneration, fisetin, rapamycin, GLP-1 drugs, exercise, and gut health, this conversation examines what it will take to move beyond population averages and toward truly personalized longevity medicine.In this episodeWhy immune health is better understood as balanced or unbalanced—not simply strong or weakHow immune resilience may relate to infection, chronic disease, healthspan, and longevityWhat happens to the thymus and T cells as we ageThe promise and unanswered questions surrounding TRIIM and thymic regenerationHow SapereX measures immune resilience and cellular senescenceWhat the evidence says about fisetin, rapamycin, GLP-1 drugs, exercise, and other interventionsWhy measuring first may be wiser than blindly expanding a longevity stackAbout Dr. Natalia MitinNatalia Mitin, PhD, is the co-founder and CEO of Sapere Bio. Her work focuses on cellular senescence, immune aging, and biomarkers designed to evaluate immune resilience and monitor how it changes over time.SapereX Longevity testingSapere BioNatalia Mitin on LinkedInResearch discussedImmune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infectionProfiling an integrated network of cellular senescence and immune resilience measures in natural agingThymic health consequences in adultsThymic health and immunotherapy outcomes in patients with cancerReversal of epigenetic aging and immunosenescent trends in humans—the TRIIM trialTRIIM-X clinical-trial registrationFisetin is a senotherapeutic that extends health and lifespanFollow the hostsJon Brudvig, PhD — Translation on SubstackGrant Fraser, MD — Longevity and Precision Medicine