Grey Zone Longevity

Longevity medicine is full of exciting ideas: rapamycin, peptides, supplements, and emerging therapies. But before worrying about any of them, have you actually assessed the diseases most likely to kill or disable you?In this episode, Jon Brudvig, PhD and Dr. Grant Fraser walk through Dr. Fraser's approach to longevity-focused primary care: identifying disease early, measuring risk more directly, and addressing the fundamentals before moving on to more speculative interventions.From cardiovascular imaging and metabolic health to cancer screening, bone density, frailty, infections, hearing loss, and cognitive decline, this conversation lays out a practical framework for understanding where you stand today—and what may be worth doing about it.In this episode:• Why “normal” labs and conventional risk scores don’t necessarily mean you’re disease-free• Why Dr. Fraser puts cardiovascular and metabolic health at the top of the longevity hierarchy• The role of coronary CT angiography, brain and vascular MRI, and other advanced imaging• ApoB, lipoprotein(a), insulin sensitivity, blood pressure, omega-3 index, hsCRP, and other biomarkers• Whole-body MRI for cancer screening—and the real tradeoff between early detection and false positives• Why Grant uses low-dose lung CT even in some nonsmokers• DEXA scans for bone density, visceral fat, body composition, and sarcopenia• How infections and vaccination become increasingly important with age• Hearing loss, dental health, vascular disease, and other overlooked contributors to cognitive decline• Why diet, exercise, sleep, stress, and conventional prevention should come before the “clever” longevity interventionsFollow the hosts:Jon Brudvig, PhD — Translation on Substackhttps://jonbrudvig.substack.comGrant Fraser, MD — Longevity & Precision Primary Carehttps://www.grantfrasermd.com

Can You Measure Immune Aging? Natalia Mitin on Immune Resilience, Senescence, and Personalized LongevityIn this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Natalia Mitin, co-founder and CEO of Sapere Bio, to explore one of longevity medicine’s biggest blind spots: how do we measure immune function and immune aging in an individual—and use that information to make better decisions?From immune resilience, T-cell exhaustion, and cellular senescence to thymic regeneration, fisetin, rapamycin, GLP-1 drugs, exercise, and gut health, this conversation examines what it will take to move beyond population averages and toward truly personalized longevity medicine.In this episodeWhy immune health is better understood as balanced or unbalanced—not simply strong or weakHow immune resilience may relate to infection, chronic disease, healthspan, and longevityWhat happens to the thymus and T cells as we ageThe promise and unanswered questions surrounding TRIIM and thymic regenerationHow SapereX measures immune resilience and cellular senescenceWhat the evidence says about fisetin, rapamycin, GLP-1 drugs, exercise, and other interventionsWhy measuring first may be wiser than blindly expanding a longevity stackAbout Dr. Natalia MitinNatalia Mitin, PhD, is the co-founder and CEO of Sapere Bio. Her work focuses on cellular senescence, immune aging, and biomarkers designed to evaluate immune resilience and monitor how it changes over time.SapereX Longevity testingSapere BioNatalia Mitin on LinkedInResearch discussedImmune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infectionProfiling an integrated network of cellular senescence and immune resilience measures in natural agingThymic health consequences in adultsThymic health and immunotherapy outcomes in patients with cancerReversal of epigenetic aging and immunosenescent trends in humans—the TRIIM trialTRIIM-X clinical-trial registrationFisetin is a senotherapeutic that extends health and lifespanFollow the hostsJon Brudvig, PhD — Translation on SubstackGrant Fraser, MD — Longevity and Precision Medicine

Are the biggest longevity gains hiding in plain sight?In this episode, Jon Brudvig and Dr. Grant Fraser sit down with Dr. Gary Fraser, a pioneering epidemiologist behind the Adventist Health Studies, to explore what decades of human data reveal about diet, lifestyle, disease risk, and lifespan. From plant-based diets and nuts to exercise, body weight, dairy, fish, and processed foods, this conversation cuts through the noise to ask a simple question: what actually seems to help people live longer, healthier lives?