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EPISODE · Jun 15, 2026 · 58 MIN

Innovating Out Loud with Jayshree Seth

from Innovating Out Loud · host JoAnn Garbin and Taryn Kutches

Three days short of 33 years at 3M, Jayshree Seth now leads the effort to put generative AI use-cases to work in R&D — which puts her between the hype and the people who have to live with it. Her message is bracing and oddly reassuring at once: AI can accelerate every step of the climb from data to wisdom, but it can't make the climb for you. Skip the human work and you don't reach the answer faster — you arrive at a confident-sounding one you can't defend. What she handed us was a working toolkit for doing it right, folded into four frameworks and one phrase we won't forget: Trace, Fast, Arcs, Flow.JoAnn and Taryn spoke with Jayshree on the May 28th episode of IOL. Here are a few key takeaways.Five takeaways1. AI can accelerate the climb from data to wisdom. It can’t make the climb for you.2. AI flips the pyramid — and DIKW becomes WIKD.3. It’s not artificial intelligence. It’s "artificial diligence."4. AI narrows the access gap and widens the judgment gap.5. AI doesn’t just change jobs — it changes the jobs to be done.ClosingThe technology is ready. The organization usually isn’t — and that gap is human. Jayshree’s whole toolkit points at the same quiet truth: AI is most useful to the people who’d still know what to do without it. Watch the full conversation for all four frameworks, the books behind them, and why she thinks the unlikely candidates are the ones true innovation needs.Check out Jayshree’s books, The Heart of Science Series: Engineering Blueprint (2024); Engineering Fine Print (2022); Engineering Footprints, Fingerprints, & Imprints (2020). All sales proceeds go towards a scholarship for women in STEM administered by Society of Women Engineers (SWE).Our next session of Innovating Out Loud is on June 25th at 9 AM PT / 12 PM ET with special guest, Larry Robertson. He’s an author, advisor, innovator, speaker, columnists and collaborative partner of the Lab! He and JoAnn will be talking about his new book, Great Question: The Art of the Ask and Getting More of What You Really Want.Never miss a live episode. Register for the series at: www.regenerouslabs.com/innovatingoutloud This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit innovatingoutloud.substack.com

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