Inside the Science: Remote tDCS Trials for MS with Dr. Charvet & Dr. Pilloni - #24 - June 7, 2025

Exploring Remote Neurostimulation in Multiple Sclerosis: A Conversation with Drs. Charvet and PilloniIn this episode of the Neurostimulation Podcast, Dr. Michael Passmore from the University of British Columbia engages with Dr. Leigh Charvet and Dr. Giuseppina Pilloni, who break down their research on remotely supervised transcranial direct current stimulation (RS-tDCS). Their discussion focuses on the feasibility, safety, and real-world applications of home-based neurostimulation treatments for multiple sclerosis (MS), targeting symptoms like fatigue and hand dexterity. They also explore broader implications for the future of personalized and accessible neurorehabilitation and explain the mechanisms and potential of tDCS as a complementary treatment option, extending to areas like depression and addiction. The episode underscores the promise of integrating therapy into the home, providing valuable insights for clinicians, researchers, and individuals living with neurological disorders.NYU Langone Clinical tDCS Service Programhttps://nyulangone.org/care-services/tdcs-program?cid=sem_google&sem_campaign_id=22139905662&sem_ad_group_id=&sem_creative_id=&gad_source=1&gad_campaignid=22139906628&gbraid=0AAAAAC9qk2v7bAhjNaz7bDanP8kgj4JsH&gclid=CjwKCAjwo4rCBhAbEiwAxhJlCTSji-MZmNiT9pziGg86R4hb7Mst8JAEHawsJKYB3-vob28tdL4D0RoC2B0QAvD_BwEClinical Research Study: HRV-Guided tDCS: Integrating a Biomarker for Clinical Utility https://clinicaltrials.med.nyu.edu/clinicaltrial/2591/hrv-guided-tdcs-integrating-biomarker/Clinical Research Study: Home-Based Transcranial Direct Current Stimulation (tDCS) for Depression in Multiple Sclerosishttps://clinicaltrials.gov/study/NCT06901687?cond=multiple%20sclerosis%20&intr=tDCS&rank=1NYU Langone’s Neuromodulation Lab https://med.nyu.edu/research/charvet-lab/Publications https://med.nyu.edu/research/charvet-lab/publications00:00 Introduction to the Neurostimulation Podcast02:06 Today's Episode: Remote Supervised tDCS for MS03:38 Meet the Experts: Dr. Charvet and Dr. Pilloni04:24 Dr. Charvet's Journey in Neurostimulation06:18 Dr. Pilloni's Background and Research08:30 The Importance of Remote Neurostimulation11:05 Study Design and Methodology13:11 Results and Implications of the Study21:18 Challenges and Future Directions26:50 Exploring Integrated Markers for Treatment Guidance28:12 The Role of Biomarkers in Depression Studies30:16 Mechanistic Studies and Brain Perfusion Insights33:01 Broad Activation and Neuroplasticity34:09 tDCS as a Complementary Treatment37:09 Challenges and Safety in Home-Based tDCS41:12 Accessibility and Future Directions44:57 Cannabis Use and Neurostimulation47:52 Closing Thoughts and Future Prospects51:12 Final Remarks and Podcast Wrap-Up