Intergenerational Trauma, Part Two: Epigenetics

A few weeks ago Katie covered a mini episode on Families & Intergenerational Trauma after a recent trip to see her family. While Katie covered a lot of detail on personal experience, on PTSD, and therapy, Ashleigh is leading this week's episode and doing a call back specifically on Epigenetics and inherited traits. Ashleigh utilizes her knowledge as a Genetic Counselor to lead this conversation. Join in and learn more!References:The Weekend University PodcastMcCartney DL, Stevenson AJ, Hillary RF, Walker RM, Bermingham ML, Morris SW, Clarke TK, Campbell A, Murray AD, Whalley HC, Porteous DJ, Visscher PM, McIntosh AM, Evans KL, Deary IJ, Marioni RE. Epigenetic signatures of starting and stopping smoking. EBioMedicine. 2018 Nov;37:214-220. doi: 10.1016/j.ebiom.2018.10.051. Epub 2018 Oct 30. PMID: 30389506; PMCID: PMC6286188.Yehuda R, Lehrner A. Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms. World Psychiatry. 2018 Oct;17(3):243-257. doi: 10.1002/wps.20568. PMID: 30192087; PMCID: PMC6127768.Alegría-Torres JA, Baccarelli A, Bollati V. Epigenetics and lifestyle. Epigenomics. 2011 Jun;3(3):267-77. doi: 10.2217/epi.11.22. PMID: 22122337; PMCID: PMC3752894.Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009 Dec;12(12):1559-66. doi: 10.1038/nn.2436. Epub 2009 Nov 8. Erratum in: Nat Neurosci. 2010 May;13(5):649. PMID: 19898468.Szyf M, McGowan P, Meaney MJ. The social environment and the epigenome. Environ Mol Mutagen. 2008 Jan;49(1):46-60. doi: 10.1002/em.20357. PMID: 18095330.Richetto J, Meyer U. Epigenetic Modifications in Schizophrenia and Related Disorders: Molecular Scars of Environmental Exposures and Source of Phenotypic Variability. Biol Psychiatry. 2021 Feb 1;89(3):215-226. doi: 10.1016/j.biopsych.2020.03.008. Epub 2020 Mar 28. PMID: 32381277.Kellermann NP. Epigenetic transmission of Holocaust trauma: can nightmares be inherited? Isr J Psychiatry Relat Sci. 2013;50(1):33-9. PMID: 24029109.Jahan N, Went TR, Sultan W, Sapkota A, Khurshid H, Qureshi IA, Alfonso M. Untreated Depression During Pregnancy and Its Effect on Pregnancy Outcomes: A Systematic Review. Cureus. 2021 Aug 17;13(8):e17251. doi: 10.7759/cureus.17251. PMID: 34540477; PMCID: PMC8448270.Monk D, Mackay DJG, Eggermann T, Maher ER, Riccio A. Genomic imprinting disorders: lessons on how genome, epigenome and environment interact. Nat Rev Genet. 2019 Apr;20(4):235-248. doi: 10.1038/s41576-018-0092-0. PMID: 30647469.McEwen BS, Bulloch K. Epigenetic impact of the social and physical environment on brain and body. Metabolism. 2019 Nov;100S:153941. doi: 10.1016/j.metabol.2019.07.005. PMID: 31610853.Cao-Lei L, de Rooij SR, King S, Matthews SG, Metz GAS, Roseboom TJ, Szyf M. Prenatal stress and epigenetics. Neurosci Biobehav Rev. 2020 Oct;117:198-210. doi: 10.1016/j.neubiorev.2017.05.016. Epub 2017 May 18. PMID: 28528960.Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12. PMID: 26410355.Bonari L, Pinto N, Ahn E, Einarson A, Steiner M, Koren G. Perinatal risks of untreated depression during pregnancy. Can J Psychiatry. 2004 Nov;49(11):726-35. doi: 10.1177/070674370404901103. PMID: 15633850. Hosted on Acast. See acast.com/privacy for more information.