Investigating Beta Cell Dysfunction and Immune Activity in Early T1D
from Diabetes Discourse
Guest: Edward Phelps, PhD Residual beta cells may persist after a type 1 diabetes (T1D) diagnosis, but how well do they continue to function? Tune in to hear Dr. Edward Phelps discuss research he presented at the 2026 European Association for the Study of Diabetes Annual Meeting that examined glucose-stimulated calcium responses in living pancreatic tissue from donors with recent-onset T1D. He explains how residual beta cells showed impaired responses to glucose regardless of the local presence of T cells, suggesting that beta cell dysfunction may extend beyond islets with substantial immune cell infiltration. Dr. Phelps is an Associate Professor in the J. Crayton Pruitt Family Department of Biomedical Engineering at the University of Florida.
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