Kanna Alkaloids: Nature's MDMA?

Show notes and references:* Please note: This was recorded prior to the election on Nov 5. We will discuss the results and predictions for the future of healthcare policy in America in our next edition.”Kanna references: Bennett, A. C., et al. "Sceletium tortuosum may delay chronic disease progression via alkaloid-dependent antioxidant or anti-inflammatory action." Journal of physiology and biochemistry 74.4 (2018): 539-547.Chiu, Simon, et al. "Proof-of-concept randomized controlled study of cognition effects of the proprietary extract Sceletium tortuosum (Zembrin) targeting phosphodiesterase-4 in cognitively healthy subjects: implications for Alzheimer’s dementia." Evidence-Based Complementary and Alternative Medicine 2014 (2014).Chiu, S., et al. "Exploring Standardized Zembrin® Extracts from the South African plant Sceletium tortuosum in Dual Targeting Phosphodiesterase-4 (PDE-4) and Serotonin Reuptake Inhibition as potential treatment in Schizophrenia." Int J Complement Alt Med 6.5 (2017): 00203.Coetzee, Dirk D., Víctor López, and Carine Smith. "High-mesembrine Sceletium extract (Trimesemine™) is a monoamine releasing agent, rather than only a selective serotonin reuptake inhibitor." Journal of Ethnopharmacology 177 (2016): 111-116.Gericke, N., and Alvaro M. Viljoen. "Sceletium—a review update." Journal of Ethnopharmacology 119.3 (2008): 653-663.Gericke, Johané. Evaluating the antidepressant-like properties of Sceletium tortuosum, alone and as adjunctive treatment. Diss. North-West University (South-Africa), 2020.Louw, Letitia. Investigation into potential endocrine disruptive effects of Sceletium tortuosum. Diss. Stellenbosch: Stellenbosch University, 2018.Reay, Jonathon, et al. "Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers." Human Psychopharmacology: Clinical and Experimental 35.6 (2020): 1-7.Reay J., Wetherell M.A., Morton E., Lillis J., Badmaev V. Sceletium tortuosum (Zembrin®) ameliorates experimentally induced anxiety in healthy volunteers. Hum. Psychopharmacol. Clin. Exp. 2020;35:1–7. doi: 10.1002/hup.2753. [PubMed] [CrossRef] [Google Scholar]    https://pubmed.ncbi.nlm.nih.gov/32761980/Schell R. Bachelor’s Thesis. Scripps Colleges; Claremont, CA, USA: 2014. Sceletium tortuosum and Mesembrine: A Potential Alternative Treatment for Depression. [Google Scholar] [Ref list]    Terburg, David, et al. "Acute effects of Sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus." Neuropsychopharmacology 38.13 (2013): 2708-2716.Van der Walt, S. Development and evaluation of a medicated chewing gum containing Sceletium tortuosum. Diss. North-West University, 2018.Villarreal M.L., Sharma A., Cardoso-Taketa A., Garcia G. A systematic updated review of scientifically tested selected plants used for anxiety disorders. Bot. Targets. 2012;2:21–39. doi: 10.2147/BTAT.S20593. [CrossRef] [Google Scholar]https://www.tandfonline.com/doi/abs/10.2147/BTAT.S20593For more detailed information on kanna's safety and how to avoid withdrawals: All You Need to Know About Kanna's Safety, Risks, and WithdrawalsPsychedelics Today interview with Rick Doblin (Ph.D.), founder of MAPS, cited in the podcast: https://psychedelicstoday.com/2024/10/15/the-fda-mdma-and-public-perception-was-the-fda-fair-to-lykos/ October 15 2024. Get full access to Neural Pharm at neuralpharm.substack.com/subscribe