Less is More in Sinusitis 🎯💊📉

from Dr RR Baliga's "Got Knowledge Doc" Podkast · host MasterMedFacts LLC

A large nationwide cohort study in JAMA compared amoxicillin-clavulanate vs amoxicillin for acute sinusitis in >500,000 adults. Treatment failure was low (~3%) with no significant difference between groups (RR 0.96). However, broader-spectrum therapy increased secondary infections, including yeast and C. difficile. The message is clear: narrow-spectrum amoxicillin remains a rational first-line choice for uncomplicated sinusitis—balancing efficacy, safety, and stewardship. Sometimes, the quiet drug wins the loud debate.

Episode metadata supplied by the publisher feed · Published Apr 22, 2026

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