Lidocaine

Trade- Xylocaine Class – Antiarrhythmic / NA+ blocker MOA – blocks sodium channels increasing the recovery period after repolarization. Suppresses automaticity in the His-Purkinje system and depolarization in the ventricles. Indication – Ventricular arrhythmias Contraindications - AV block, Bleeding, thrombocytopenia, Use caution in bradycardia, hypovolemia, cardiogenic shock, adams stokes syndrome, WPW Side effects – Toxicity ( signs may include anxiety, apprehension, euphoria, nervousness, disorientation, dizziness, blurred vision, facial paresthesias, tremors, hearing disturbances, slurred speech, seizures, sinus bradycardia.) Seizures without warning, cardiac arrhythmias, hypotension, cardiac arrest, pain at injection site. Dosing Pulseless v- tach and v-fib Adult: – 1-1.5mg/kg IV/IO may repeat at half the original dose (0.5 to 0.75mg/kg) every 5-10 mins to a max dose of 3mg/kg. Maintenance drip 1-4mg/min Pedi: 1mg/kg IV/IO (max 100mg) Maintenance 20-50 mcg/kg/min Perfusing ventricular rhythms Adult: 0.5-0.75mg/kg IV/IO repeat every 5-10mins to a max dose of 3mg/kg Pedi: 1mg/kg IV/IO may repeat every 5-10 mins to a max of 3mg/kg