Longevity Papers 2025-07-28

In this episode of Longevity Papers, we analyze groundbreaking research from July 21-27, 2025: 1. LLM Predicts Organ Aging (Li et al., Nature Medicine): A large language model outperforms epigenetic clocks in mortality prediction using health reports. Discussing clinical potential and black-box limitations. (https://pubmed.ncbi.nlm.nih.gov/40702324 ) 2. DNA Methylation Atlas (Jacques et al., bioRxiv): Cross-tissue analysis identifies PCDHGA1 and NAD+ pathways as universal aging drivers. Debate on epigenetic entropy vs. resilience. (https://www.biorxiv.org/content/10.1101/2025.07.21.665830v1 ) 3. New Senolytic Target (Okamura et al., bioRxiv): GLS1 inhibitor BPTES eliminates senescent cells via glutamine metabolism. Exploring selectivity and translation hurdles. (https://www.biorxiv.org/content/10.1101/2025.07.22.666220v1 ) 4. Superager Brain Networks (Zhao et al., bioRxiv): fMRI-based connectome predicts resistance to Alzheimer’s. Can we enhance resilience neurostimulation? (https://www.biorxiv.org/content/10.1101/2025.07.20.665707v1 ) Full list at longevitypapers.com.