Longevity Papers Podcast

Episodes

1. 37

   Harvard Finds Aging Microbiome Harms the Brain, Plus 4 More Breakthroughs - Longevity Papers Mar 2026

   In this episode of Longevity Papers, we analyze five standout papers from longevitypapers.com covering the past four weeks of longevity research (February-March 2026): 1) Microbiome depletion rejuvenates the aging brain (Gasperini, Holton, Limone et al., Harvard University, February 15, 2026,...

   Mar 15, 2026

   19m
2. 36

   H2S Gasotransmitters, Lymphatic Rejuvenation, HIV Cure, and First Human Rapamycin Study - Feb 2026

   In this episode, we discuss five groundbreaking papers from longevitypapers.com on mechanisms of aging and potential interventions: 1) Enhanced non-enzymatic H2S generation via natural diallyl sulforated compounds extends lifespan and healthspan in mice (Cáliz-Molina et al., Cell Metabolism,...

   Feb 11, 2026

   34m
3. 35

   Longevity Papers 2025-12-14

   A Fourfold Male-Specific Lifespan Extension via Canonical Insulin/IGF-1 Signaling (Russell et al., University of Alabama at Birmingham, December 5, 2025, BioRxiv, https://www.biorxiv.org/content/10.64898/2025.12.02.691904v1 ) - We explore how the daf-2 mutation extends male C. elegans lifespan by...

   Dec 14, 2025

   34m
4. 34

   AI, Splicing, and Nuclear Tension: 4 New Papers on Aging

   In this episode, we analyze four standout papers from longevity research (November 17–30, 2025). The sources indicate that none achieve the paradigm-shifting breakthrough required for decades-long (10+ year) human lifespan extension. 1. Targeting Nuclear Tension to Rejuvenate Blood (Paper #74)...

   Nov 30, 2025

   24m
5. 33

   Longevity Papers 2025-11-14

   In this episode of Longevity Papers, we critically analyze the five most impactful papers from this week (November 10-14, 2025) selected from longevitypapers.com for biotech researchers and longevity enthusiasts. 1) 'circHERC1-A telomerase activator' (Yumeng Cui et al., Beijing Institute of...

   Nov 14, 2025

   12m
6. 32

   Longevity Papers 2025-11-02

   In this episode of Longevity Papers podcast, we discuss three cutting-edge papers on aging mechanisms and potential interventions, featured this week on longevitypapers.com. 1) Decay in transcriptional information flow is a hallmark of cellular aging (Emison et al., Yale University, October 30,...

   Nov 2, 2025

   15m
7. 31

   Longevity Papers 2025-10-19

   In this episode of Longevity Papers, we critically analyze five research papers from the week of October 13-19, 2025, curated from longevitypapers.com: 1) Mutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular...

   Oct 19, 2025

   31m
8. 30

   Longevity Papers 2025-09-19

   In this episode of Longevity Papers, we critically analyze the week of September 15-19, 2025 papers from longevitypapers.com for biotech researchers. We examine five papers: 1) The DREAM Complex Links Somatic Mutation, Lifespan, and Disease (Koch et al., UC San Diego, September 18, 2025, bioRxiv,...

   Sep 19, 2025

   36m
9. 29

   Longevity Papers 2025-09-12

   This week on Longevity Papers, we didn't find so many interesting papers so we go back to a classic research by Cynthia Kenyon, but also analyze recent research from longevitypapers.com 1) The first long-lived mutants: discovery of the insulin/IGF-1 pathway for ageing. (Kenyon, Cynthia 12 January...

   Sep 11, 2025

   46m
10. 28

    Longevity Papers 2025-09-02

    In this episode of Longevity Papers, we critically analyze recent research with appropriate skepticism for biotech researchers and longevity enthusiasts. First we discuss the ARDD conference that took last week in Copenhagen, including a replacement panel, and a related paper from Nature Aging…

    more
    Sep 2, 2025

    54m
11. 27

    Longevity Papers 2025-08-12

    In this episode of Longevity Papers, we critically analyze three moderately interesting research papers from longevitypapers.com: 1) Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging (Mishra et al., Yale School of...

    Aug 12, 2025

    13m
12. 26

    Longevity Papers 2025-08-04

    In this episode of Longevity Papers, we critically analyze this weeks research with appropriate skepticism for biotech researchers and longevity enthusiasts. This week represents a typical collection where 95% of papers are incremental advances rather than paradigm-shifting discoveries. We…

    more
    Aug 4, 2025

    13m
13. 25

    Longevity Papers 2025-07-28

    In this episode of Longevity Papers, we analyze groundbreaking research from July 21-27, 2025: 1. LLM Predicts Organ Aging (Li et al., Nature Medicine): A large language model outperforms epigenetic clocks in mortality prediction using health reports. Discussing clinical potential and black-box...

    Jul 28, 2025

    18m
14. 24

    Longevity Papers 2025-07-18

    In this episode of Longevity Papers, we analyze groundbreaking research for biotech longevity scientists: JULY 2025 BREAKTHROUGHS: 1. Beyond the Pseudogene: p17/PERMIT as Mitochondrial Trafficking Protein (Albayram et al., Medical University of South Carolina, July 17) • Reclassification of "junk...

    Jul 22, 2025

    21m
15. 23

    Longevity Papers 2025-06-26

    In this episode of Longevity Papers, we critically analyze five cutting-edge research papers for biotech researchers and longevity enthusiasts, sourced from longevitypapers.com: 1) An Antagonistically Pleiotropic Gene Regulates Vertebrate Growth, Maturity and Aging (Moses et al., biorxiv, June…

    more
    Jun 26, 2025

    16m
16. 22

    Longevity Papers 2025-06-20

    This week on Longevity Papers, we dissect five groundbreaking papers from the week of June 16th, 2025, sourced from LongevityPapers.com. We prioritize surprising findings from credible labs that challenge existing models in aging research. 1. The Mediator complex subunit Med19 extends healthy...

    Jun 20, 2025

    18m
17. 21

    Longevity Papers 2025-06-13: A single factor for safer cellular rejuvenation

    In this episode of Longevity Papers, we critically analyze a groundbreaking new paper for biotech researchers and longevity enthusiasts: A single factor for safer cellular rejuvenation by Camillo et al. from Shift Bioscience, posted to bioRxiv on June 6, 2025...

    Jun 13, 2025

    24m
18. 20

    Longevity Papers 2025-06-05

    In this episode of Longevity Papers, we critically analyze five cutting-edge research papers for biotech researchers and longevity enthusiasts: 1) The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan (Gkioni et al., Max Planck Institute for…

    more
    Jun 5, 2025

    21m
19. 19

    Longevity Papers 2025-05-29

    In this episode of Longevity Papers, we critically analyze five groundbreaking research papers for biotech researchers and longevity enthusiasts: 1) Lysosomes Signal through Epigenome to Regulate Longevity across Generations (Zhang et al., HHMI Janelia Research Campus, May 24, 2025,...

    May 29, 2025

    22m
20. 18

    Longevity Papers 2025-05-20

    In this episode of Longevity Papers, we critically analyze five cutting-edge research papers for biotech researchers and longevity enthusiasts: 1) "Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia" (Kelu…

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    May 20, 2025

    16m
21. 17

    Longevity Papers 2025-04-17

    Paper Title: Boosting Cellular Longevity Through Intracellular ATP Modulation Authors: Naci Oz, Hetian Su, Praveen Patnaik, Derek C. Prosser, Vyacheslav M. Labunskyy, Rohil Hameed, Vadim N. Gladyshev, Nan Hao, Alaattin Kaya Institution: University of Virginia, University of California San Diego,...

    Apr 17, 2025

    15m
22. 16

    Full paper analysis: Epigenetic editing at individual age-associated CpGs affects the genome-wide...

    Paper: Epigenetic editing at individual age-associated CpGs affects the genome-wide epigenetic aging landscape. Authors: Liesenfelder, S., Elsafi Mabrouk, M.H., Iliescu, J. *et al.*. The corresponding author is Wolfgang Wagner. Journal: Nature Aging Published: 24 March 2025. DOI:...

    Apr 9, 2025

    17m
23. 15

    Longevity Papers 2025-04-03

    Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species (March 31, 2025) Institution: Southwest Medical University, Luzhou, Sichuan, China Relevance: The study finds that ferroptosis—a form of iron-dependent cell death—is a key driver of cellular senescence.…

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    Apr 3, 2025

    14m
24. 14

    Longevity Papers 2025-03-27

    Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence Lu, J., Rao, S. R., Knowles, H. ... · cell biology · Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK ·...

    Mar 27, 2025

    28m
25. 13

    Longevity Papers 2025-03-20

    1. Inhibition of PIKfyve kinase induces senescent cell death by suppressing lysosomal exocytosis and leads to improved outcomes in a mouse model of idiopathic pulmonary fibrosis https://www.biorxiv.org/content/10.11... Authors: Barkovskaya, A., Kim, K., Shankar, A. et al. Journal: Biorxiv...

    Mar 20, 2025

    22m
26. 12

    Longevity Papers 2025-03-13

    Longevity Papers 2025-03-13 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Mar 13, 2025

    40m
27. 11

    Longevity Papers 2025-03-06

    Longevity Papers 2025-03-06 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Mar 6, 2025

    33m
28. 10

    Longevity Papers 2025-02-27

    Longevity Papers 2025-02-27 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Feb 27, 2025

    16m
29. 9

    Longevity Papers 2025-02-20

    Longevity Papers 2025-02-20 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Feb 20, 2025

    23m
30. 8

    Longevity Papers 2025-02-13

    Longevity Papers 2025-02-13 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Feb 13, 2025

    47m
31. 7

    Longevity Papers 2025-02-05

    Longevity Papers 2025-02-05 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Feb 5, 2025

    44m
32. 6

    Longevity Papers 2025-01-30

    Longevity Papers 2025-01-30 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Jan 30, 2025

    17m
33. 5

    Longevity Papers 2025-01-23

    Longevity Papers 2025-01-23 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Jan 23, 2025

    19m
34. 4

    Longevity Papers 2025-01-16

    Longevity Papers 2025-01-16 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Jan 16, 2025

    17m
35. 3

    Longevity Papers 2025-01-09

    Longevity Papers 2025-01-09 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Jan 9, 2025

    23m
36. 2

    Longevity Papers 2025-01-02

    Longevity Papers 2025-01-02 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Jan 2, 2025

    13m
37. 1

    Longevity Papers 2024-12-27

    Longevity Papers 2024-12-27 The Longevity Papers podcast focuses on the latest research papers in longevity biotech. This podcast episode covers a few of the tens of papers in https://longevitypapers.com, which finds the latest interesting papers with longevity focus from preprint servers. The...

    Dec 27, 2024

    14m