Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395 episode artwork

EPISODE · May 7, 2026 · 1H 20M

Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395

from The Aging Well Podcast · host Jeff Armstrong

The longevity space is exploding—with new drugs, supplements, influencers, and bold promises appearing almost daily. But what actually holds up under scientific scrutiny?In this rapid-fire return to The Aging Well Podcast, Dr. Jeff Armstrong welcomes back Dr. Matt Kaeberlein, one of the world’s leading researchers in the biology of aging. Together, they move quickly through a curated list of popular longevity drugs and supplements—asking what works, what’s overhyped, what’s promising but premature, and what may carry real risk.They also discuss how to evaluate so-called “longevity experts,” how to think about evidence in an emerging field, and what Dr. Kaeberlein is personally doing right now to optimize his own healthspan. The episode closes with a thoughtful conversation on psilocybin—where it may fit in mental health, and whether it has any legitimate role in longevity science.This is a clear-eyed, intellectually honest tour through the modern longevity landscape.Please, support The Aging Well Podcast by hitting the ‘like’ button, subscribing/following the podcast, sharing with a friend, and….Tip Jar! All donations support this podcast to keep it going. https://paypal.me/theagingwellpodcastBUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastNutritional Biochemical Inc. (NBI) | Trusted supplement. NBI stands 100% behind the quality of their formulations and the science on which they’re based. | Click the following link and use the discount code AGINGWELL for 10% off: https://shop.nbihealth.com/agingwellBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellJigsaw Health | Trusted supplements. “It’s fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3KneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELL*We receive commission on these purchases. Thank you.

The longevity space is exploding—with new drugs, supplements, influencers, and bold promises appearing almost daily. But what actually holds up under scientific scrutiny?In this rapid-fire return to The Aging Well Podcast, Dr. Jeff Armstrong welcomes back Dr. Matt Kaeberlein, one of the world’s leading researchers in the biology of aging. Together, they move quickly through a curated list of popular longevity drugs and supplements—asking what works, what’s overhyped, what’s promising but premature, and what may carry real risk.They also discuss how to evaluate so-called “longevity experts,” how to think about evidence in an emerging field, and what Dr. Kaeberlein is personally doing right now to optimize his own healthspan. The episode closes with a thoughtful conversation on psilocybin—where it may fit in mental health, and whether it has any legitimate role in longevity science.This is a clear-eyed, intellectually honest tour through the modern longevity landscape.Please, support The Aging Well Podcast by hitting the ‘like’ button, subscribing/following the podcast, sharing with a friend, and….Tip Jar! All donations support this podcast to keep it going. https://paypal.me/theagingwellpodcastBUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastNutritional Biochemical Inc. (NBI) | Trusted supplement. NBI stands 100% behind the quality of their formulations and the science on which they’re based. | Click the following link and use the discount code AGINGWELL for 10% off: https://shop.nbihealth.com/agingwellBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellJigsaw Health | Trusted supplements. “It’s fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3KneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELL*We receive commission on these purchases. Thank you.

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Longevity Rapid Fire with Dr. Matt Kaeberlein: Hype, Hope, and What Actually Works | Ep. 395

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This episode was published on May 7, 2026.

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The longevity space is exploding—with new drugs, supplements, influencers, and bold promises appearing almost daily. But what actually holds up under scientific scrutiny?In this rapid-fire return to The Aging Well Podcast, Dr. Jeff Armstrong...

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