Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? | Masterjohn Q&A Files #226

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt  Plenty more at https://chrismasterjohnphd.com/support! Question: Low cystine & sulfate, mid-range methionine, high homocysteine: what to do? My default position on this would be, you probably don't have a problem recycling homocysteine to methionine. And that might explain why, I'm assuming this is in the fasting state, your homocysteine is only slightly elevated. Now, if you mean by slightly elevated, if you mean slightly elevated outside of the lab's reference range, then that's very elevated. And so I would look at that a little bit differently, but especially when paired with the low cystine and sulfate levels, it sounds like you have a low rate of the transsulfuration pathway or the CBS enzyme, which is the first step in that pathway, which takes homocysteine down to cysteine, which then can be metabolized to sulfate. If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice. Access the show notes, transcript, and comments here. Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.