MCAT DNA Replication Explained: Semi-Conservative Copying, Okazaki Fragments, & Mutation Repair

from Jack Westin MCAT Podcast · host Jack Westin

In this episode we connect genetics + central dogma to the next big step: how cells copy DNA and what happens when it goes wrong.What you’ll learn (MCAT-high yield):Semi-conservative replication: why each daughter DNA has one old + one new strandOrigins of replication & replication bubblesKey enzymes: helicase, SSB proteins, topoisomerase, DNA pol III & I, primase, ligaseLeading vs. lagging strands and Okazaki fragmentsProofreading & repair: exonuclease activity, mismatch repair, nucleotide excision repair (UV/thymine dimers)Mutation types: silent, nonsense, frameshift (+ why location matters)Where this shows up in cell cycle, cancer biology, and classic experimental set-ups (knockouts)Perfect for MCAT Bio/Biochem passages that love replication, mutations, and repair pathways.Want to learn more? Shoot us a text at 415-855-4435 or email us at [email protected]! 📱📌 Free Academic Advising: https://calendly.com/academic-advising-4/jack-westin-academic-advising?utm_source=spotify&utm_medium=podcast💻 Try our Chrome Extension (video solutions to every AAMC passage) https://tinyurl.com/4jw5pad8📚 Free Resources: https://jackwestin.com?utm_source=spotify&utm_medium=podcast🎓 Live Education Sessions: https://jackwestin.com/sessions?utm_source=spotify&utm_medium=podcast👨🏻‍🏫 Courses: https://jackwestin.com/courses?utm_source=spotify&utm_medium=podcast🙋 Tutoring: https://jackwestin.com/services/live-online-mcat-tutoring?utm_source=spotify&utm_medium=podcast📸 Follow Us On Instagram: https://www.instagram.com/jackwestinmcat?utm_source=spotify&utm_medium=podcast👥 Join our Facebook Study Group: https://www.facebook.com/groups/freemcatprep?utm_source=spotify&utm_medium=podcast

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This episode was published on October 21, 2025.

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