Metformin + ivermectin + rapamycin (etc) << a ‘longevity’ drugs explainer

“Some of these have data and others… not so much." Thanks for listening to Age Well with Dr Sophie Shotter – please rate and review the show if you get a moment. Some notes and studies etc: Metformin is increasingly thought to protect against cancer, heart disease, and potentially even Alzheimer’s. Read more: https://pubmed.ncbi.nlm.nih.gov/28802803-metformin-reduces-all-cause-mortality-and-diseases-of-ageing-independent-of-its-effect-on-diabetes-control-a-systematic-review-and-meta-analysis/ Scientists have also shown that Metformin encourages the growth of certain good gut bacteria, which leads to increased production of short-chain fatty acids. Read more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681099/ A recent longitudinal study shows we still need more research and data. Read more: https://peterattiamd.com/a-recent-metformin-study-casts-doubts-on-longevity-indications/ Dr Sophie mentioned the Targeting Aging with Metformin or TAME study. Some studies have also shown that metformin can inhibit muscle growth. Read more: https://www.lifespan.io/news/metformin-and-resistance-training-downside-and-upside/#:~:text=Metformin%20restricts%20muscle%20building%20but%20makes%20gene%20expression%20more%20youthful.&text=A%20new%20study%20published%20in,it%20promotes%20youthful%20gene%20expression. A 2025 American Society of Clinical Oncology Annual Meeting looked at a study of ivermectin in combination with immunotherapy for patients with breast cancer and showed no significant benefit. Read: https://www.oncologynewscentral.com/asco-conference-coverage Dr Sophie mentioned Primeadine® Original Spermidine. MORE STUDIES: https://www.uea.ac.uk/about/news/article/anti-aging-drug-rapamycin-extends-lifespan-as-effectively-as-eating-less https://www.sciencedirect.com/science/article/pii/S0531556523000876 Find out more by heading to https://drsophieshotter.com/ Follow Dr Sophie on Instagram… https://www.instagram.com/drsophieshotter/?hl=en …and Tik Tok https://www.tiktok.com/@drsophieshotter?lang=en This podcast was produced by https://thepodcastpeople.co/ Co-host: https://fionamattesini.co.uk/ The content in this podcast is for general information purposes only and is not meant to serve as medical advice or to replace or substitute advice given by, or consultation with, your doctor or any other healthcare professional. Please contact your healthcare provider if you have any questions or concerns about your health. Dr Sophie Shotter, her company and any employees or representatives are not liable for any claims arising out of or in connection with this podcast.