Metformin + ivermectin + rapamycin (etc) << a ‘longevity’ drugs explainer

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Some notes and studies etc:

Metformin is increasingly thought to protect against cancer, heart disease, and potentially even Alzheimer’s. Read more: https://pubmed.ncbi.nlm.nih.gov/28802803-metformin-reduces-all-cause-mortality-and-diseases-of-ageing-independent-of-its-effect-on-diabetes-control-a-systematic-review-and-meta-analysis/

Scientists have also shown that Metformin encourages the growth of certain good gut bacteria, which leads to increased production of short-chain fatty acids. Read more: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681099/

A recent longitudinal study shows we still need more research and data. Read more: https://peterattiamd.com/a-recent-metformin-study-casts-doubts-on-longevity-indications/

Dr Sophie mentioned the Targeting Aging with Metformin or TAME study.

Some studies have also shown that metformin can inhibit muscle growth. Read more: https://www.lifespan.io/news/metformin-and-resistance-training-downside-and-upside/#:~:text=Metformin%20restricts%20muscle%20building%20but%20makes%20gene%20expression%20more%20youthful.&text=A%20new%20study%20published%20in,it%20promotes%20youthful%20gene%20expression.

A 2025 American Society of Clinical Oncology Annual Meeting looked at a study of ivermectin in combination with immunotherapy for patients with breast cancer and showed no significant benefit. Read: https://www.oncologynewscentral.com/asco-conference-coverage

Dr Sophie mentioned Primeadine® Original Spermidine.

MORE STUDIES:

https://www.uea.ac.uk/about/news/article/anti-aging-drug-rapamycin-extends-lifespan-as-effectively-as-eating-less

https://www.sciencedirect.com/science/article/pii/S0531556523000876

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