EPISODE · Feb 15, 2023 · 18 MIN
Mini Episode: Bridging the Gap- Bupropion's not your average wide QRS with Dr. Travis Olives
from The Poison Lab
Rohr 2004- Gap junction blockade can cause a wide QRS Vink 2004 Connexin 43 is the most important protein for connexon formation and cardiac signal transmissionCallier 2012- Bupropion does not block sodium channels, and does exhibit similar effects on the cardiac action potential as known gap junction Burnham 2014 Bupropion has an IC50 for connexin 43 >50 uMol, larger than other drugs such as fluoextine and lamotrigineShaikh Quereshi 2014 Bupropion interferes with connexin43 production and localization in chicken cardiac myoctes at concentration >50 uMolA Morel DilemmaSupport the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe GOTTA PICCEM Poisonous Mushroom Game!The Poisonus Fungus Amongus Children's Book!Full book reading (6 minutes!)Tox trinkets (Rep the show at home!)Reach the showEmail: [email protected] Show ResourcesRyan's Medical Games and ResourcesShow Website
What this episode covers
In this episode Ryan is Joined by Dr. Travis Olives MD (Associate medical director of Minnesota Poison Center, Medical Toxicologist, Emergency Physician) to discuss the implications of bupropion's effect on gap junctions and its apparent lack of effect on sodium channel, when managing wide QRS arrythmias in bupropion overdose
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Mini Episode: Bridging the Gap- Bupropion's not your average wide QRS with Dr. Travis Olives
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