Mini Episode: Fundamentals: Testings Tests, Addictions vs Dependence, How Do We Alter Drug Absorption, What Do Drugs Do?

Concepts in this episode Ryan and Toxo introduce their roles while explaining the current state of toxicology and what exactly a poison is. testing our testsSensitivity: Rate of Positive test in those who have the diseaseSpecificity: Rate of negative test in those without the diseasePositive predictive value: True positive/ True Positive + False PositiveNegative predictive value: True negative/True negative + False negativePharmacokinetics and dynamics(PK) Bioavailablity = Amount of drug available to be used by the bodyOral Bioavailablity= Dose- Fraction excreted unchanged- Fraction metabolized in gut- Fraction metabolized by liver How drugs interact with the body (PD)Agonist- stimulates receptorPartial agonist- Activation of receptor with ceiling effect, never achieves maximal activationAntagonist- Prevents receptor activationInverse agonist- induces an opposite effect as an agonist after binding receptorAddiction vs dependanceAddiction- Relationship between user and substanceA few definitions but frequently involving consequences in life from use and loss of control over use of substanceDependence- Physiologic changes in body due to chronic useDown regulation of stimulated receptorsPhysiologic basis for tolerance and withdrawalA Morel DilemmaSupport the showReview the show where ever your listeningGet Messages from Toxo (Join the Newsletter!)Join as a supporting memberAd free episodesBonus content and early accessDiscounts and give aways on GOTA PICCEM Mushroom card gameThe GOTTA PICCEM Poisonous Mushroom Game!The Poisonus Fungus Amongus Children's Book!Full book reading (6 minutes!)Tox trinkets (Rep the show at home!)Reach the showEmail: [email protected] Show ResourcesRyan's Medical Games and ResourcesShow Website