Mitochondria, Mistakes, 🧬 InflammAgeing

🔬 Exciting new insights from Nature (2025)! When mitochondria run low on the right building blocks (deoxyribonucleotides), they mistakenly weave ribonucleotides into their DNA 🧬. The result? Fragile mitochondrial DNA gets expelled, setting off the cGAS–STING pathway and fueling inflammation 🔥—a key feature of ageing and senescence.   🧪 In MGME1-deficient mice, this process drives renal inflammation, while supplementation with deoxyribonucleosides 💊 can calm the storm.   ✨ A major step in understanding "inflammageing" and potential interventions for age-related diseases.   #Mitochondria #DNA #Ageing #Inflammation #NaturePaper