Oncometabolites and The Heart

Oncometabolites and The Heart Dr RR Baliga 'Got Knowledge Doc' PodKasts for Cardio-Oncologists Baliga RR, Young JB. Energizing Diastole Heart Fail Clin. 2008;4(1):ix‐xiii. Energizing Diastole Sulkowski, P.L., Oeck, S., Dow, J. et al. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature (2020). Tumour metabolites hinder DNA repair   Krebs Cycle Nobel Lecture   Ivosidenib and Cardiogenic Shock   Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A.    D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev.   Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer. J Cardiovasc Transl Res.   Krebs Cycle Primer Khan Academy Taegtmeyer H, et al  Oncometabolic Tracks in the Heart. Circ Res. 2017