Pediatric Hereditary Angioedema: Diagnosis, Treatment & Long-Term Management

Hereditary angioedema (HAE) is a rare but potentially life-threatening genetic disorder that often presents during childhood, yet diagnosis is frequently delayed for many years. Early recognition and timely treatment can dramatically improve quality of life and reduce the risk of serious complications, including airway obstruction.In this episode of Hope & Histamine: The Paediatric Allergy Podcast, we explore the latest evidence and practical approaches to diagnosing and managing paediatric hereditary angioedema (HAE). Whether you’re a paediatrician, allergy specialist, emergency clinician, trainee, nurse, or allied healthcare professional, this episode provides a comprehensive overview of this important condition.In this episode, we discuss:Understanding the genetics and pathophysiology of hereditary angioedemaClinical features that distinguish HAE from allergic angioedemaCommon triggers and patterns of attacks in childrenDiagnostic investigations, including complement testing and genetic confirmationRecognising red flags for life-threatening laryngeal oedemaAcute management of HAE attacksShort-term and long-term prophylactic treatment optionsThe role of C1 esterase inhibitor replacement therapy, bradykinin-targeted treatments and emerging therapiesFamily screening, genetic counselling and transition to adult servicesPractical tips for emergency action plans and improving patient outcomesJoin us as we review current guidelines, discuss real-world clinical challenges, and share practical insights to help clinicians recognise hereditary angioedema earlier and deliver evidence-based care for children and young people living with HAE.Source:Farkas, H. et al. (2026) 'International Guideline on the Diagnosis and Management of Pediatric Patients With Hereditary Angioedema', Allergy. Available at: https://onlinelibrary.wiley.com/doi/10.1111/all.70207. DOI: 10.1111/all.70207.🎧 Listen now on Apple Podcasts, Spotify, Amazon Music, and YouTubeDisclaimer: The information shared in this podcast and on this website is not intended to replace professional medical advice, diagnosis, or treatment. Always consult your doctor or a qualified healthcare provider with any questions you may have about a medical condition. Please don't ignore or delay seeking medical advice based on content from this podcast or website.Buy me a coffee: https://coff.ee/goodlifecreationsHope & Histamine: The Paediatric Allergy Podcast brings you expert interviews, evidence-based discussions and practical clinical updates on paediatric allergy, immunology and related conditions to support healthcare professionals in everyday practice.🎧 Listen and subscribe:https://hopeandhistaminepodcasts.buzzsprout.comIf you enjoyed this episode, please subscribe, leave a review, and share it with colleagues to help improve awareness of hereditary angioedema and advance the care of children with rare allergic and immunological conditions.Send us Fan MailSupport the showBrought to you by - Goodlife Creations (2026). Music by - Denys Kyshchuk from Pixabay.