Percutaneous Coronary Intervention Mortality Breakdown. 02/16/26

Welcome to Cardiology Today – Recorded February 16, 2026. This episode summarizes 5 key cardiology studies on topics like heart transplant rejection and Percutaneous coronary intervention. Key takeaway: Percutaneous Coronary Intervention Mortality Breakdown.. Article Links: Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons) Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). (The American journal of cardiology) Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. (The American journal of cardiology) Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. (The American journal of cardiology) Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/percutaneous-coronary-intervention-mortality-breakdown-02-16-26/ Featured Articles Article 1: ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692363 Summary: This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article 2: Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41478442 Summary: This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article 3: Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41421515 Summary: This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article 4: Revascularization in Patients Over 75 With Acute Coronary Syndrome. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41391816 Summary: This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article 5: Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41692131 Summary: This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Transcript Today’s date is February 16, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. ADAR1 and RIPK1 orchestrate the ZBP1-mediated PANoptosis and mouse heart transplant rejection. This study found that Z-DNA induced PANoptosis in human microvascular endothelial cells through ZBP1. Researchers observed that ADAR1 and R. I. P. K. one collaboratively regulated the activation of the ZBP1-R. I. P. K. three complex, controlling PANoptosis in a time-dependent manner. The interaction of ADAR1 with ZBP1 specifically protected against Z-DNA-induced cell death. These findings reveal crucial molecular mechanisms driving PANoptosis and its potential relevance in heart transplant rejection. Article number two. Global Longitudinal Strain Reference Values in the Hispanic/Latino Population: Echocardiographic Study of Latinos (ECHO-SOL). This study established global longitudinal strain reference values for the Hispanic/Latino population using data from the Echocardiographic Study of Latinos. Researchers defined the 95th-percentile lower limit of normal global longitudinal strain values from a healthy reference sample. These established values provide essential clinical benchmarks for detecting early cardiac dysfunction in this specific demographic. The findings offer crucial guidance for assessing heart failure risk factors and interpreting echocardiographic results in Hispanic/Latino patients. Article number three. Optical Coherence Tomography versus Intravascular Ultrasound-Guided Primary Percutaneous Coronary Intervention in ST-Elevation Myocardial Infarction: A Multicenter Propensity-Matched Analysis. This multicenter analysis compared clinical outcomes of optical coherence tomography versus intravascular ultrasound guidance for primary percutaneous coronary intervention in patients with S. T.-elevation myocardial infarction. The study utilized data from 2777 S. T.-elevation myocardial infarction patients who underwent primary percutaneous coronary intervention at 12 Japanese hospitals. Researchers found comparative data on the use of both imaging modalities, which are recommended by current guidelines for percutaneous coronary intervention guidance. These findings contribute to understanding the relative performance and clinical utility of optical coherence tomography and intravascular ultrasound in this critical patient population. Article number four. Revascularization in Patients Over 75 With Acute Coronary Syndrome. This retrospective analysis investigated revascularization strategies in patients over 75 years old presenting with acute coronary syndromes. Observational data previously showed that coronary artery bypass graft was associated with improved one-year outcomes, including lower rates of death and rehospitalization, compared to percutaneous coronary intervention and medical management in general acute coronary syndrome patients with multivessel coronary artery disease. This study provided specific data addressing these outcomes in the elderly population. The findings contribute to clinical decision-making for optimal revascularization strategies in acute coronary syndrome patients aged over 75. Article number five. Death Following Percutaneous Coronary Intervention: Data from the PROGRESS-COMPLICATIONS registry. This study analyzed mortality following percutaneous coronary intervention using data from the P. R. O. G. R. E. S. S. minus C. O. M. P. L. I. C. A. T. I. O. N. S. registry. Among 22503 patients undergoing percutaneous coronary intervention, 115 patients, representing 0.5 percent, died before hospital discharge. Researchers found that 15 patients, 13.0 percent of the mortalities, died during the procedure, while 10 patients, 8.7 percent, died within the first 24 hours post-procedure, and 90 patients, 78.3 percent, died more than 24 hours after the intervention. The study also revealed that patients who died exhibited a high burden of comorbidities. Thank you for listening. Don’t forget to subscribe. Keywords heart transplant rejection, Percutaneous coronary intervention, P. C. I. mortality, comorbidities, Optical coherence tomography, Hispanic/Latino population, in-hospital death, intravascular ultrasound, percutaneous coronary intervention, Revascularization, coronary artery bypass graft, S. T.-elevation myocardial infarction, ZBP1, RIPK1, PROGRESS-COMPLICATIONS registry, echocardiography, heart failure risk factors, elderly patients, reference values, ADAR1, PANoptosis, intravascular imaging, Global longitudinal strain, acute coronary syndrome. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Percutaneous Coronary Intervention Mortality Breakdown. 02/16/26 first appeared on Cardiology Today.