🧠 Precision, Prevention, Progress: Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer

🚨 New in NEJM — The ALASCCA Trial 🧬 Low-dose aspirin (160 mg/day) reduced colorectal cancer recurrence in patients with PIK3CA, PIK3R1, or PTEN mutations 🎯   ✅ 3-year recurrence: 7.7% (aspirin) vs 14–17% (placebo) ✅ Group A HR: 0.49 | Group B HR: 0.42 ✅ NNT as low as 6 in stage III rectal cancer 💥 ⚠️ Slight increase in adverse events   🧠 Editorial calls it a new standard of care: 🔬 Genotype early + 💊 Start aspirin early = 📉 Lower recurrence   📖 Read both the trial and editorial in NEJM, Sept 2025 #ColorectalCancer #PrecisionOncology #Aspirin #PIK3CA #NEJM #OncologyTrials #Genomics #AdjuvantTherapy #ALASCCA #ClinicalTrials