"Prepared for destruction? Soul ties? Generational curses?"

My uncle offered his house to me at no charge, and now I'm wondering if it's God's will. How do we reconcile the fact that God doesn't want anyone to perish with the truth that some were "prepared for destruction"? Some churches have rejected me or paid no attention to me. I'm wondering if I've ruined my calling, and I need community. Can you help? I grew up in Africa, and I wonder how I can break soul ties and no longer be subject to generational curses.