Quick Hits: The Women's Hormone Masterclass: A Deep Dive Into Testosterone, Dutasteride, SHBG, & Menopause Weight Gain with Dr. Kyle Gillett episode artwork

EPISODE · Mar 10, 2026 · 17 MIN

Quick Hits: The Women's Hormone Masterclass: A Deep Dive Into Testosterone, Dutasteride, SHBG, & Menopause Weight Gain with Dr. Kyle Gillett

from The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Listen to the full episode Download the full episode on Apple or on your favorite podcast platforms. In this quick hits I sit down with Dr. Gillett, to exam the complex world of women's hormones today. We'll be focusing on androgens like testosterone, DHEA, and dihydrotestosterone, and their profound impact on female health. Dr. Gillett provides insights on the role of binding globulins, hormone replacement therapy, and the interplay between insulin and androgens. We also discuss the challenges of menopausal weight gain, the benefits of GLP-1 medications for weight loss, and practical strategies anyone can use for maintaining lean body mass. In this episode we discuss: How androgens such as testosterone, DHEA, and dihydrotestosterone affect women's well-being. Why sex hormone binding globulin (SHBG) is critical for hormone dynamics and stability. Understanding the impact of thyroid binding globulin and cortisol binding globulin on hormone balance. How hormone replacement therapy (HRT) influences women's bodies, especially regarding androgens. Managing testosterone replacement therapy to avoid virilization symptoms like facial hair and voice changes. The role of DHT blockers in managing androgen-related conditions. How SHBG can be harnessed for overall hormone stability and health benefits. Challenges of menopausal weight gain and how hormonal changes affect body composition. Why integrating proper lifestyle habits is essential alongside GLP-1 medications for effective weight loss. How to maintain lean body mass through hormone therapy and lifestyle changes. How oral contraceptives and other synthetic hormones impact SHBG levels and overall hormone balance. The significance of SHBG levels for individuals on hormone replacement therapy or contraceptives. Exploring different forms of testosterone administration, including subcutaneous and intramuscular injections. How estrogen and progesterone influence testosterone levels through negative feedback inhibition. How poor sleep quality and hormonal changes contribute to menopausal weight gain. The paradoxical effects of hormone replacement therapy on body composition and fat gain. Why high SHBG must be paired with adequate hormone levels to avoid feeling unwell. Discussing the challenges faced when SHBG levels are artificially high due to medication. Kyle Gillett https://gilletthealth.com/     Sponsors Get 50% off the Energy Reboot Program hackmyage.com use coupon code HORMONES50.     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

NOW PLAYING

Quick Hits: The Women's Hormone Masterclass: A Deep Dive Into Testosterone, Dutasteride, SHBG, & Menopause Weight Gain with Dr. Kyle Gillett

0:00 17:43

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

Frequently Asked Questions

How long is this episode of The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health?

This episode is 17 minutes long.

When was this The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health episode published?

This episode was published on March 10, 2026.

What is this episode about?

Listen to the full episode Download the full episode on Apple or on your favorite podcast platforms. In this quick hits I sit down with Dr. Gillett, to exam the complex world of women's hormones today. We'll be focusing on androgens like...

Can I download this The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health episode?

Yes, you can download this episode by clicking the download button on the episode player, or subscribe to the podcast in your preferred podcast app for automatic downloads.
URL copied to clipboard!