Real Hope For Many Cancer Patients - Dr. Lewis Cantley: Ep 46

Dr. Lewis Cantley has made significant advances in cancer research stemming from his discovery of the signalling pathway phosphoinositide 3-kinase (Pi3K) in 1984.  It is an enzyme that mediates pretty much everything that insulin does, in the liver, in the fat cells, and it mediates the lowering of serum glucose levels because it drives glucose into the muscle, AND into tumours. Since tumours thrive on glucose, they thought to develop a Pi3 Kinase inhibitor in order to try to treat tumours but the inhibitor resulted in startling rises in blood glucose levels.  In order to manage this they tried using many different drugs, including the use of Metformin with very limited success. Most people had to drop out of the treatments as their glucose levels rose dangerously high. Also, for those who could stay on the treatment only got, on average a life extension of just short of one year. His team then tried advocating a very strict ketogenic diet for a small control group and had great success for those who did stay in the diet (which was most of them).  Together with the results they have on combining the ketogenic diet with a Pi3K inhibitor in rat models which, in his words, produced miraculous results they now have formal human clinical trials underway which I am confident will produce miraculous results as well.