S.G.L.T.2i Benefits Pre-Heart Failure in Older Adults 11/09/25

Welcome to Cardiology Today – Recorded November 09, 2025. This episode summarizes 5 key cardiology studies on topics like voltage-gated sodium channel and heart failure. Key takeaway: S.G.L.T.2i Benefits Pre-Heart Failure in Older Adults. Article Links: Article 1: The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural and functional indicators and biochemical markers in Older Adults with Hypertension and Pre-Heart Failure. (Cardiology) Article 2: FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking. (Circulation research) Article 3: The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. (Circulation research) Article 4: Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. (Circulation research) Article 5: Vascular Niches Are the Primary Hotspots in Cardiac Aging. (Circulation research) Full episode page: https://podcast.explainheart.com/podcast/s-g-l-t-2i-benefits-pre-heart-failure-in-older-adults-11-09-25/ Featured Articles Article 1: The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural and functional indicators and biochemical markers in Older Adults with Hypertension and Pre-Heart Failure. Journal: Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41201974 Summary: This study investigated the impact of sodium-glucose cotransporter 2 inhibitors on cardiac structure and cardiorenal function in older adults with hypertension and pre-heart failure. Eighty-eight patients were randomized to receive dapagliflozin or conventional treatment. The research evaluated changes in N-terminal pro-brain natriuretic peptide, which is a key biomarker for heart failure, among other indicators. This study contributes to understanding the therapeutic potential of dapagliflozin in preventing heart failure progression in a vulnerable older population. Article 2: FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41200819 Summary: This research explored the role of fibroblast growth factor homologous factor 13, known as F.G.F.13, in regulating cardiac conduction, specifically examining its influence on connexin 43 gap junctions independent of voltage-gated sodium channels. The study assessed cardiac conduction and cardiomyocyte action potentials in mice lacking F.G.F.13, revealing a novel mechanism by which F.G.F.13 impacts impulse propagation through connexin 43 trafficking. These findings establish a crucial, non-canonical pathway for arrhythmia development and provide a new target for antiarrhythmic strategies. Article 3: The βIV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41196954 Summary: This study investigated how the cytoskeletal protein beta-I.V.-spectrin, in complex with S.T.A.T.3, regulates the orientation of cardiac hypertrophic growth. Researchers evaluated this complex to understand its role in determining whether cardiac hypertrophy manifests as beneficial concentric or detrimental eccentric growth. The findings reveal a key mechanism influencing cardiac remodeling, which is crucial for distinguishing adaptive from maladaptive hypertrophy and potentially guiding future therapeutic interventions for heart failure. Article 4: Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41090220 Summary: This study examined mitochondrial calcium handling and cellular redox state in atrial fibrillation patients. Researchers isolated cardiac myocytes from patient-derived right atrial biopsies to subject them to workload transitions. The study revealed that atrial fibrillation is associated with impaired atrial mitochondrial calcium handling, identifying a potential new mechanistic target for understanding and treating this common arrhythmia. Article 5: Vascular Niches Are the Primary Hotspots in Cardiac Aging. Journal: Circulation research PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41090219 Summary: This research explored the microenvironmental changes within the heart that contribute to age-related cardiac dysfunction, fibrosis, and inflammation. By combining single-nucleus R.N.A. sequencing and spatial transcriptomics in aged mice hearts, the study identified vascular niches as primary hotspots for age-related alterations in cardiac tissue. These findings provide a detailed map of cellular and molecular changes in the aging heart, offering specific targets for interventions to mitigate cardiovascular aging. Transcript Today’s date is November 09, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. The effect of Sodium-dependent glucose transporter 2 Inhibitors on cardiac structural and functional indicators and biochemical markers in Older Adults with Hypertension and Pre-Heart Failure. This study investigated the impact of sodium-glucose cotransporter 2 inhibitors on cardiac structure and cardiorenal function in older adults with hypertension and pre-heart failure. Eighty-eight patients were randomized to receive dapagliflozin or conventional treatment. The research evaluated changes in N-terminal pro-brain natriuretic peptide, which is a key biomarker for heart failure, among other indicators. This study contributes to understanding the therapeutic potential of dapagliflozin in preventing heart failure progression in a vulnerable older population. Article number two. F.G.F.13 Regulates V.G.S.C.-Independent Cardiomyocyte Impulse Propagation via C.x.43 Trafficking. This research explored the role of fibroblast growth factor homologous factor 13, known as F.G.F.13, in regulating cardiac conduction, specifically examining its influence on connexin 43 gap junctions independent of voltage-gated sodium channels. The study assessed cardiac conduction and cardiomyocyte action potentials in mice lacking F.G.F.13, revealing a novel mechanism by which F.G.F.13 impacts impulse propagation through connexin 43 trafficking. These findings establish a crucial, non-canonical pathway for arrhythmia development and provide a new target for antiarrhythmic strategies. Article number three. The beta I.V.-Spectrin/S.T.A.T.3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth. This study investigated how the cytoskeletal protein beta-I.V.-spectrin, in complex with S.T.A.T.3, regulates the orientation of cardiac hypertrophic growth. Researchers evaluated this complex to understand its role in determining whether cardiac hypertrophy manifests as beneficial concentric or detrimental eccentric growth. The findings reveal a key mechanism influencing cardiac remodeling, which is crucial for distinguishing adaptive from maladaptive hypertrophy and potentially guiding future therapeutic interventions for heart failure. Article number four. Impaired Atrial Mitochondrial Calcium Handling in Patients With Atrial Fibrillation. This study examined mitochondrial calcium handling and cellular redox state in atrial fibrillation patients. Researchers isolated cardiac myocytes from patient-derived right atrial biopsies to subject them to workload transitions. The study revealed that atrial fibrillation is associated with impaired atrial mitochondrial calcium handling, identifying a potential new mechanistic target for understanding and treating this common arrhythmia. Article number five. Vascular Niches Are the Primary Hotspots in Cardiac Aging. This research explored the microenvironmental changes within the heart that contribute to age-related cardiac dysfunction, fibrosis, and inflammation. By combining single-nucleus R.N.A. sequencing and spatial transcriptomics in aged mice hearts, the study identified vascular niches as primary hotspots for age-related alterations in cardiac tissue. These findings provide a detailed map of cellular and molecular changes in the aging heart, offering specific targets for interventions to mitigate cardiovascular aging. Thank you for listening. Don’t forget to subscribe. Keywords voltage-gated sodium channel, heart failure, N-terminal pro-brain natriuretic peptide, F.G.F.13, cardiac hypertrophy, dapagliflozin, hypertension, cardiac aging, sodium-glucose cotransporter 2 inhibitors, mitochondrial calcium, vascular niches, redox state, pre-heart failure, atrial myocytes, cardiac remodeling, cardiac energetics, fibroblast growth factor homologous factor 13, arrhythmia, connexin 43, cardiac fibrosis, atrial fibrillation, beta-I.V.-spectrin, S.T.A.T.3, spatial transcriptomics, single-nucleus R.N.A. sequencing. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post S.G.L.T.2i Benefits Pre-Heart Failure in Older Adults 11/09/25 first appeared on Cardiology Today.