Seeds. Signals. Sanctuary: The Biology of Brain Metastases 🧠

  🧠 Brain metastases remain a clinical frontier—common, complex, and still lethal. In Science Signaling, Chafe et al. unpack the biology: Blood Brain Barrier traversal, metabolic rewiring, and immune evasion.   Key insight: metastasis is not just spread—it is adaptation.   From adenosine-driven immunosuppression to neuronal-like tumor states, new therapeutic doors are opening.   Precision oncology must now think beyond the primary tumor.   #BrainMetastases #Oncology #NeuroOncology #Immunotherapy #PrecisionMedicine