🫀 Sense. 🧠 Signal. 🛡️ Scar. A Heart–Brain–Immune Loop in Myocardial Infarction

🫀🧠🛡️ Sense. Signal. Scar.   A striking Cell study reframes myocardial infarction as a systems disease, not a heart-only event. Using single-cell and spatial transcriptomics in murine MI, the authors identify a triple-node heart–brain–immune loop: TRPV1-positive vagal sensory neurons (injury sensing) → hypothalamic paraventricular nucleus AT1aR neurons (central integration) → superior cervical ganglion IL-1β signaling (sympathetic–immune effector arm).   Intervening at any node improved ejection fraction, reduced infarct size, and normalized autonomic balance—pointing to neuroimmune modulation as a new therapeutic frontier beyond myocardium-centric care.   📌 Key takeaway: Treat the circuit, not just the scar. 📖 Yadav et al., Cell (2026)