Sex and Age Differences of Major Cardiovascular Events in Patients After Percutaneous Coronary Intervention

Sex and Age Differences of Major Cardiovascular Events in Patients After Percutaneous Coronary Intervention J Chin Med Assoc . 2023 Oct 10. doi: 10.1097/JCMA.0000000000001011 Abstract Background: Women usually have higher risk after receiving percutaneous coronary interventions (PCIs) than men with coronary artery disease (CAD). The aim of this study was to investigate the association of sex differences with future outcomes in CAD patients undergoing PCI, to assess the role of age, and to extend observed endpoints to stroke and congestive heart failure.   Methods: 6,647 patients with CAD who received successful PCIs. The associations between clinic outcomes and sex were analyzed. The primary outcome was major cardiovascular events (MACE), including cardiac death, nonfatal myocardial infraction, and nonfatal stroke. The secondary outcome was MACE and hospitalization for heart failure (total CVevents).   Results: During a mean of 52.7 months of follow-up, 4833 men and 1614 women received PCI. Univariate and multivariate analyses showed that women were independently associated with an increased risk of cardiac death (HR: 1.78; 95% CI: 1.32-2.41), hospitalization for heart failure (HR: 1.53, 95% CI: 1.23-1.89), MACE (HR: 1.34; 95% CI: 1.10-1.63), and total CV events (HR: 1.39; 95% CI: 1.20-1.62). In the subgroup analysis, women under 60 years of age had higher cardiovascular risks than men of the same age category.   Conclusion: Women with CAD after successful PCI had poorer cardiovascular outcomes than men. Additionally, younger women (age <60 years) were especially associated with a higher risk of developing future adverse cardiovascular outcomes. Disclaimer: Lupin makes no representation or warranty of any kind, expressed or implied, regarding the accuracy, adequacy, validity, reliability, availability, or completeness of any scientific information shared by the HCP on the ­­­STAR UPDATE podcast. You should not allow the contents of this to substitute for your own medical judgment, which you should exercise in evaluating the information on this website.