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Star Update Podcast - Cardiology News Summaries

by ImagicaHealth

Want to hear the latest in cardiology research, reviews, and perspectives? Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Our summaries are available monthly.

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Episodes

  1. Heart Failure Outcomes with SGLT2 Inhibitors in Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis

    Heart Failure Outcomes with SGLT2 Inhibitors in Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis DOI: https://doi.org/10.3390/medicina62010069 Abstract Background and Objectives: Type 2 diabetes mellitus (T2DM) substantially increases the risk of heart failure (HF) and worsens…

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  2. Potent P2Y12 Inhibitor Monotherapy Versus Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Systematic Review and Meta-Analysis

    Potent P2Y12 Inhibitor Monotherapy Versus Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Systematic Review and Meta-Analysis DOI: 10.1177/10760296261422490 Abstract BackgroundThe optimal duration of dual antiplatelet therapy (DAPT) after...

  3. Aspirin Combined With Ticagrelor or Clopidogrel in STEMI Patients With Diabetes Mellitus and Poor Glycemic Control Undergoing Primary PCI: A Multicenter Retrospective Cohort Study

    Aspirin Combined With Ticagrelor or Clopidogrel in STEMI Patients With Diabetes Mellitus and Poor Glycemic Control Undergoing Primary PCI: A Multicenter Retrospective Cohort Study DOI: 10.1002/ccd.70503 Abstract Background: The safety and efficacy of aspirin combined with ticagrelor or…

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  4. β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials

    β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysisof randomised controlled trials Lancet-2025 Sep 13;406(10508):1128-1137. doi: 10.1016/S0140-6736(25)01592-2. Epub 2025 Aug 30. Abstract Background: The effects of β-blocker…

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  5. Circadian variation in ST-segment elevation myocardial infarction: a nationwide analysis of onset, treatment delays, and culprit artery patterns

    Circadian variation in ST-segment elevation myocardial infarction: a nationwide analysis of onset, treatmentdelays, and culprit artery patterns Pol Arch Intern Med. 2026 Jan 7:17188. doi: 10.20452/pamw.17188 Abstract Introduction: ST-segment elevation myocardialinfarction (STEMI) onset follows a...

  6. Impact of Early Percutaneous Coronary Intervention on Long-Term Survival in Patients With Acute Myocardial Infarction

    Impact of Early Percutaneous Coronary Intervention on Long-Term Survival in Patients With Acute Myocardial InfarctionCureus 18(1): e101145. DOI 10.7759/cureus.101145 Abstract Background: Early percutaneous coronary intervention(PCI) is the recommended standard of care for acute myocardial...

  7. Lower Ticagrelor Dosing in the Dual Antiplatelet Regimen for Neurointerventional Procedures

    Lower Ticagrelor Dosing in the Dual Antiplatelet Regimen for Neurointerventional Procedures https://doi.org/10.1136/jnis-2024-022536 Abstract Background Ticagrelor, a P2Y12 inhibitor, offersa rapid onset and consistent platelet inhibition, making it a viable alternative for dual antiplatelet...

  8. Initiation of SGLT2 inhibitors versus mineralocorticoid receptor antagonists as third-line therapy in heart failure with reduced ejection fraction: a nationwide cohort study

    Initiation of SGLT2 inhibitors versus mineralocorticoid receptor antagonists as third-line therapy in heart failurewith reduced ejection fraction: a nationwide cohort study Lancet Reg Health Eur . 2025 Oct 27:60:101510. doi:10.1016/j.lanepe.2025.101510. Abstract Background: Heart failure with...

  9. Incidence and In-Hospital Outcomes of Bradycardia or Atrioventricular Conduction Disorder in Patients With Type 2 Myocardial Infarction: A Nationwide Inpatient Analysis

    Incidence and In-Hospital Outcomes of Bradycardia or Atrioventricular Conduction Disorder in Patients With Type 2Myocardial Infarction: A Nationwide Inpatient Analysis https://doi.org/10.1002/joa3.70243 ABSTRACT Background Type 2 myocardial infarction (T2MI), caused by an imbalancebetween oxygen...

  10. Pharmacological Evaluation of Ticagrelor and Aspirin Versus Clopidogrel and Aspirin Pretreatment on Infarct Artery Flow in Patients with Acute STEMI

    Pharmacological Evaluation of Ticagrelor and Aspirin Versus Clopidogrel and Aspirin Pretreatment on Infarct Artery Flowin Patients with Acute STEMI Pharmaceuticals 2025, 18(12), 1856; https://doi.org/10.3390/ph18121856 Abstract Background and Objectives: Dual antiplatelet therapy(DAPT) with…

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  11. Intravascular imaging-guided percutaneous coronary intervention for acute myocardial infarction according to ACC/AHA lesion classification

    Intravascular imaging-guided percutaneous coronary intervention for acute myocardial infarction according to ACC/AHA lesion classification https://doi.org/10.1016/j.rec.2025.12.001 Abstract Introduction and objectives: Despite the favorableprognosis associated with intravascular imaging...

  12. β-blocker and clinical outcomes in patients after myocardial infarction: a systematic review and meta-analysis

    β-blocker and clinical outcomes in patients after myocardial infarction: a systematic review and meta-analysis Eur J Clin Pharmacol. 2025 Dec;81(12):1807-1817. Abstract Background and objective: While current clinicalguidelines generally advocate for beta-blocker therapy following acute…

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  13. Efficacy and safety of ticagrelor versus clopidogrel in acute myocardial infarction-associated cardiogenic shock: a propensity score-matched analysis

    Efficacy and safety of ticagrelor versus clopidogrel in acute myocardial infarction-associated cardiogenic shock: apropensity score-matched analysis https://doi.org/10.1093/eurheartj/ehaf784.2070 Abstract Background Cardiogenic shock secondary to acute myocardial infarction (AMICS) is a critical...

  14. Differential Impact of Metoprolol Formulations on Heart Failure Outcomes: A Multi-center Study

    Differential Impact of Metoprolol Formulations on Heart Failure Outcomes: A Multi-center Study https://doi.org/10.1016/j.yjcafi.2025.10.010 ABSTRACT Background Despite widespread use of metoprolol formulations in heart failure (HF), direct comparative evidence of theirclinical outcomes remains...

  15. Prognostic Implications of Heart Failure Rehospitalization in Adults with CHD & Clinical Benefits of Medical Therapy

    Prognostic Implications of Heart Failure Rehospitalization in Adults with CHD & Clinical Benefits of Medical Therapy https://doi.org/10.1016/j.ijcchd.2025.100640 ABSTRACT Background The risk factors for heart failure (HF) rehospitalization, and the effect of guideline directed medical therapy...

  16. Beta-Blockers after Myocardial Infarction in Patients without Heart Failure

    Beta-Blockers after Myocardial Infarction in Patients without Heart Failure N Engl J Med . 2025 Nov 13;393(19):1901-1911. doi: 10.1056/NEJMoa2505985 Abstract Background: The evidence supporting beta-blockertherapy after myocardial infarction was established before the introduction of modern...

  17. Impact of digoxin versus beta-blocker in patients with coexistent atrial fibrillation and heart failure: a target trial emulation

    Impact of digoxin versus beta-blocker in patients withcoexistent atrial fibrillation and heart failure: a target trial emulation BMC Med . 2025 Oct 21;23(1):575. doi: 10.1186/s12916-025-04408-0. Abstract Background: This study aimed to compare the impact of digoxin versus beta-blocker on adverse...

  18. Dual Versus Single Antiplatelet Therapy After Transcatheter Aortic Valve Implantation for Bioprosthetic Valve Failure

    Dual Versus Single Antiplatelet Therapy After Transcatheter Aortic Valve Implantation for Bioprosthetic Valve Failure https://www.jacc.org/doi/10.1016/j.jcin.2025.09.018 ABSTRACT Background: Single antiplatelet therapy (SAPT) is the standard treatment after transcatheter aortic valve intervention...

  19. 1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention

    1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention Drugs Aging . 2025 Oct;42(10):975-985. doi:10.1007/s40266-025-01235-z. Abstract Purpose: Compared with long-term dual antiplatelet therapy (DAPT, aspirin...

  20. Drug Utilization Patterns and Adherence to Guideline-Directed Therapy in Acute Myocardial Infarction: A Prospective Observational Study

    Drug Utilization Patterns and Adherenceto Guideline-Directed Therapy in Acute Myocardial Infarction: A ProspectiveObservational Study International Journal of Life Sciences, Biotechnology andPharma Research Vol. 14, No. 10, October 2025 DOI:10.69605/ijlbpr_14.10.2025.11 ABSTRACT Background: Acute...

  21. The use of beta-blockers for heart failure with reduced ejection fraction in the era of SGLT2 inhibitors - are we still afraid to up-titrate?

    The use of beta-blockers for heart failure with reduced ejection fraction in the era of SGLT2 inhibitors - are westill afraid to up-titrate? Heart Vessels . 2025 Sep;40(9):797-804.doi: 10.1007/s00380-025-02525-7. Abstract Beta-blockers are one of the four major pillars of guideline-directed…

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  22. Angiotensin receptor-neprilysin inhibitors and mortality among patients with heart failure with reduced ejection fraction

    Angiotensin receptor-neprilysin inhibitors and mortality among patients with heart failure with reducedejection fraction https://doi.org/10.1016/j.amjcard.2025.08.063 Abstract Background While trial evidence supports the benefit of angiotensin receptor-neprilysin inhibitor (ARNI) therapy in heart...

  23. Comparison between clopidogrel and ticagrelor in CYP2C19 loss-of-function alleles coronary artery disease and stroke patients: a meta-analysis

    Comparison between clopidogrel and ticagrelor in CYP2C19 loss-of-function alleles coronary artery disease andstroke patients: a meta-analysis Eur J Clin Pharmacol. 2025 Sep;81(9):1241-1256. Abstract Background: It is suggested that in patientswith coronary artery diseases (CAD) and stroke, the…

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  24. β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysis of randomised controlled trials

    β blockers after myocardial infarction with mildly reduced ejection fraction: an individual patient data meta-analysisof randomised controlled trials Lancet. 2025 Sep 13;406(10508):1128-1137. Abstract Background: The effects of β-blocker therapy on clinicaloutcomes in patients with myocardial...

  25. ST-elevation myocardial infarction and air pollution: relationship between hourly air pollution and cardiovascular risk factors

    ST-elevation myocardial infarction and air pollution: relationship between hourly air pollution and cardiovascular risk factors J Cardiovasc Med (Hagerstown). 2025 Aug 1;26(8):412-419. Abstract Objective: Air pollution contributes to cardiovascular diseases through oxidative stress, inflammation,...

  26. SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction: Design paper

    SGLT2 inhibitor with and without ALDosterone AntagonIst for heart failure with preserved ejection fraction:Design paper ESC Heart Fail. 2025 Aug;12(4):3134-3144. doi: 10.1002/ehf2.15294 Abstract Background: Sodium glucose co-transporter 2 inhibitors (SGLT2i) and mineralocorticoid receptor...

  27. Beta-blocker interruption effects on blood pressure and heart rate after myocardial infarction: the AβYSS trial

    Beta-blocker interruption effects on blood pressure and heart rate after myocardial infarction: the AβYSS trial Eur Heart J 2025 Aug 1;46(29):2894-2902. doi: 10.1093/eurheartj/ehaf170. Abstract Background and aims: This study aims to report theeffects of β-blocker interruption on blood pressure...

  28. 1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention

    1-Month Versus 12-Month Dual Antiplatelet Therapy for Patients with Chronic Total Occlusion After Successful Percutaneous Coronary Intervention Drugs Aging. 2025 Aug 2. doi: 10.1007/s40266-025-01235z. Abstract Purpose: Compared with long-term dual antiplatelet therapy (DAPT, aspirin with...

  29. Effects of moderate physical training program in post-myocardial infarction patients with arterial hypertension

    Effects of moderate physical trainingprogram in post-myocardial infarction patients with arterial hypertension Eur J Transl Myol. 2025 Jul 10. doi: 10.4081/ejtm.2025.13943 Abstract The clinical effectiveness of physical training in a cardiac rehabilitation program (CRP) was assessed in...

  30. Combined effects of clonal hematopoiesis of intermediate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study

    Combined effects of clonal hematopoiesis of intermediate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study https://doi.org/10.1016/j.phrs.2025.107852 Abstract Clonal hematopoiesis of intermediate potential (CHIP) is a...

  31. Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study

    Early β-Blocker Use and Clinical Outcomesin Acute Myocardial Injury: A Retrospective Cohort Study Am J Med. 2025 Jul;138(7):1090-1098.e6. Abstract Background: Acute myocardial injury is defined by elevated cardiac troponin levels with a rising and/or falling pattern, and is associated with...

  32. A Retrospective Cohort Study on Long-Term Outcomes of Ticagrelor Versus Clopidogrel After Retrograde Percutaneous Coronary Intervention for Chronic Total Occlusion

    A Retrospective Cohort Study on Long-TermOutcomes of Ticagrelor Versus Clopidogrel After Retrograde Percutaneous Coronary Intervention for Chronic Total Occlusion Am J Cardiovasc Drugs. 2025 Jul 12. doi:10.1007/s40256-025-00750-z. Abstract Background: Chronic total occlusion (CTO) affects 15-25%…

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  33. Antiplatelet and Anticoagulant Therapy in the 2025 ACC/AHA Guideline for Acute Coronary Syndromes: Key Recommendations

    Antiplatelet and Anticoagulant Therapy in the 2025 ACC/AHA Guideline for Acute Coronary Syndromes: KeyRecommendations JACC. 2025 Jun, 85 (22) 2074–2078 The 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for theManagement of Patients With Acute Coronary Syndromes (ACS), published in this issue of JACC,...

  34. Pragmatic Use of Ticagrelor: Improving Outcomes in Medical Management of Acute Coronary Syndrome (PracTiCal India Study)

    Pragmatic Use of Ticagrelor: ImprovingOutcomes in Medical Management of Acute Coronary Syndrome (PracTiCal India Study) Journal of Indian College of Cardiology ():10.4103/jicc.jicc_73_24, June 05, 2025. | DOI: 10.4103/jicc.jicc_73_24 Abstract Background: The utilization of ticagrelor in the…

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  35. Exploring the Impact of Beta-Blockers Post-Acute Myocardial Infarction in Patients with Preserved Ejection Fraction: A Meta-Analysis

    Exploring the Impact of Beta-Blockers Post-Acute Myocardial Infarction in Patients with Preserved Ejection Fraction: A Meta-Analysis J. Clin. Med. 2025, 14(11), 3969; https://doi.org/10.3390/jcm14113969 Abstract Background/Objectives: Previous research has establishedthat beta-blockers...

  36. The 2025 Guideline for the Management of Patients With Acute Coronary Syndromes: Asian Perspective

    The 2025 Guideline for the Management of Patients With Acute Coronary Syndromes: Asian Perspective https://www.jacc.org/doi/full/10.1016/j.jacc.2025.04.011 The 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for theManagement of Patients with Acute Coronary Syndromes introduces key updates that may...

  37. Effect of Body Mass Index in Patients With Cardiogenic Shock Requiring Microaxial Flow Pump

    Effect of Body Mass Index in Patients With Cardiogenic Shock Requiring Microaxial Flow Pump JACC: Asia. May 04, 2025. Epublished DOI:10.1016/j.jacasi.2025.03.003 Abstract Background The impact of obesity on mortality in patients with cardiogenic shock (CS) requiring microaxial flow pumps (mAFP)...

  38. The Impact of Preoperative P2Y12 Inhibitors on Short- and Long-Term Outcomes Following Percutaneous Coronary Intervention

    The Impact of Preoperative P2Y12 Inhibitors on Short- and Long-Term Outcomes Following Percutaneous CoronaryIntervention DOI: 10.1016/j.jscai.2025.103226 ExternalLink Background The preoperative usage of P2Y12 inhibitors primarily aim to reduce thrombotic complications for percutaneous coronary...

  39. Incidence and Risk Factors of De Novo Postpartum Hypertension: Understanding Links to Long-Term Cardiovascular Risk

    Incidence and Risk Factors of De Novo Postpartum Hypertension: Understanding Links to Long-Term Cardiovascular Risk JACC Adv. 2025 Jun, 4 (6_Part_1) 101756 Abstract Background Individuals developing hypertensive disorders of pregnancy face a 2- to 5-fold risk of long-term cardiovascular disease....

  40. Aspirin vs Clopidogrel vs Ticagrelor Monotherapy Compared to 12 Months of DAPT Following PCI; A Systematic Review and Meta-Analysis

    Aspirin vs Clopidogrel vs Ticagrelor Monotherapy Compared to 12 Months of DAPT Following PCI; A Systematic Review and Meta-Analysis DOI: 10.1016/j.jscai.2025.103158 ExternalLink Background Short-term Dual Antiplatelet Therapy (DAPT) may reduce the risk of bleeding after Percutaneous Coronary...

  41. Does Timing of Coronary Artery Bypass Grafting after ST-Elevation Myocardial Infarction Impact Early- and Long-Term Outcomes?

    Does Timing of Coronary Artery Bypass Grafting after ST-Elevation Myocardial Infarction Impact Early- and Long-Term Outcomes? DOI: 10.1055/s-0044-1787851 Abstract Background: The optimal timing of surgicalrevascularization after ST-elevation myocardial infarction (STEMI) is controversial, with…

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  42. TADCLOT Trial: A Double Blind Randomized Controlled Trial Comparing Twice a Day Clopidogrel vs. Ticagrelor in Reducing Major Cardiac Events in Patients with Acute STEMI Undergoing PCI

    Rationale and Design of the TADCLOT Trial: A Double Blind Randomized Controlled Trial Comparing Twice a DayClopidogrel vs. Ticagrelor in Reducing Major Cardiac Events in Patients with Acute STEMI Undergoing Primary Percutaneous Coronary Intervention DOI: 10.1016/j.ahj.2025.03.021 Abstract...

  43. In-hospital use of beta-blockers for critically ill patients with acute heart failure: Whether and when to initiate

    In-hospital use of beta-blockers for critically ill patients with acute heart failure: Whether and when to initiate DOI: 10.1016/j.jclinane.2025.111824 Abstract Background: The use of beta-blockers during hospitalization for acute heart failure (AHF) remains controversial. This study aimed to...

  44. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee

    1. Dual antiplatelet therapy is recommended for patients with acute coronary syndromes (ACS). Ticagrelor or prasugrel is recommended in preference to clopidogrel in patients with ACS who are undergoing percutaneous coronary intervention (PCI). In patients with non–ST-segment elevation ACS who are...

  45. Impact of Metabolic Syndrome on Clinical Profile and Prognosis in Patients with Acute ST-Elevation Myocardial Infarction: a Cross-Sectional Study

    Impact of Metabolic Syndrome on Clinical Profile and Prognosis in Patients with Acute ST-Elevation MyocardialInfarction: a Cross-Sectional Study https://link.springer.com/article/10.1007/s42399-025-01822-6 Abstract Metabolic syndrome (MS) has gained attention as a newly discovered risk factor for...

  46. Assessing the application of American Heart Association (AHA) guidelines in the management of heart failure with reduced ejection fraction

    Assessing the application of American Heart Association (AHA) guidelines in the management of heart failure withreduced ejection fraction https://link.springer.com/article/10.1186/s43044-025-00629-z Heart failure (HF) is a significant global health issue. Appropriate and timely treatment at…

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  47. 1The “Silent Enemy” Called Renal Artery Stenosis: A Mini-Review:

    The “Silent Enemy” Called Renal Artery Stenosis: A Mini-Review: J. Vasc. Dis. 2025, 4(1), 10; https://doi.org/10.3390/jvd4010010 Renal artery stenosis (RAS) is a vascular condition characterized by narrowing of one or both renal arteries, leading to reduced blood flow to the kidneys, activation…

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  48. Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study

    Early β-Blocker Use and Clinical Outcomes in Acute Myocardial Injury: A Retrospective Cohort Study https://doi.org/10.1016/j.amjmed.2025.02.029 Abstract Background Acute myocardial injury is defined by elevated cardiactroponin (cTn) levels with a rising and/or falling pattern, and is associated...

  49. Impact of controlled stepwise reperfusion during primary percutaneous coronary intervention on patients with ST-elevation myocardial infarction

    Impact of controlled stepwise reperfusion during primary percutaneous coronary intervention on patients with ST-elevation myocardial infarction Abstract Objective: The aim of this study is to examine the impact of controlled stepwise reperfusion by modulating pre-dilation balloonpressure during...

  50. Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis

    Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: asystematic review and meta-analysis DOI https://doi.org/10.1186/s13098-025-01616-9 Abstract Background The significant burden of cardiovascular diseases underscores the necessity for...

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ABOUT THIS SHOW

Want to hear the latest in cardiology research, reviews, and perspectives? Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Our summaries are available monthly.

HOSTED BY

ImagicaHealth

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health fitness medicine

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Want to hear the latest in cardiology research, reviews, and perspectives? Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD...

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