SOUL: Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

SOUL is a large randomized trial of oral semaglutide in adults with type 2 diabetes and established cardiovascular or kidney disease. In this Hormone Insight clinical evidence discussion, we cover the five-part PICO, the primary MACE result, absolute event rates, the non-significant kidney secondary outcome, patient selection, and limits of generalization. Fahad narration, clean voice-only production, no music. Primary source: PMID 40162642. DOI 10.1056/NEJMoa2501006. For healthcare professionals. This episode is an evidence discussion, not a substitute for the original paper, product information, local guidance, or individualized clinical judgment.

Episode metadata supplied by the publisher feed · Published Aug 22, 2026

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SOUL: Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes

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