Stop Biohacking Broken Biology: Mitochondria, Methylene Blue & the Real Path to Longevity with Dr. Scott Sherr

Dr. Scott Sherr is a clinician, hyperbaric medicine specialist, co-founder of Troscriptions, and one of the founding faculty of the Health Optimization Medicine and Practice nonprofit — and in this return episode, he comes with a very different perspective than his first appearance. What changed? He stopped putting everyone in the chamber. In this conversation, Scott and Freddie unpack the two hyperbaric chamber deaths that shook the industry in 2025 — what actually went wrong, what safety standards clinics and home users are missing, and why a sympathetically dominant nervous system may render even the best biohacking tools completely ineffective. From there they go deep on mitochondrial function as the master upstream driver of energy, detox, digestion, healing, and longevity — and why most people need to subtractbefore they can optimize. The second half of this episode is a complete masterclass on methylene blue — what it actually does at the mitochondrial level, how to find your ideal dose (hint: you'll know within three to five days), why 94% of American adults are metabolically compromised enough to benefit from it, and how one ultramarathoner shaved three hours off his Leadville 100 finish time using it strategically. Scott and Freddie also tackle epigenetic age testing, immunosenescence, the dopamine-draining effects of smartphones on libido and focus, and why screen time may be the most underrated threat to your nervous system recovery. Plus — a full breakdown of the Troscriptions product suite: TruCalm, TruZ, TruImmune, and methylene blue's role in each.Episode Highlights [04:27] – Dr. Scott explains how his work now spans clinical care, practitioner training, and product development [06:35] – Why mitochondrial function has become the foundation of his approach to health and recovery [07:42] – What likely caused recent hyperbaric chamber accidents and why safety protocols matter [13:12] – Why stacking devices inside a chamber creates unnecessary risk [15:16] – The problem with influencer protocols and overcomplicating health routines [18:52] – Soft-shell vs. hard-shell chambers and how pressure impacts oxidative stress [22:42] – A practical framework for intensive vs. maintenance hyperbaric use [27:59] – Why direct mitochondrial testing is limited and how metabolomics fills the gap [29:55] – Common signs of mitochondrial dysfunction, from brain fog to poor recovery [35:53] – Dr. Scott revisits methylene blue and challenges common misconceptions [39:28] – Why most people may benefit from mitochondrial support despite “not being sick” [41:44] – How to think about dosing and what a proper response should feel like [44:04] – The role of sympathetic dominance in blocking healing and recovery [46:04] – Why longevity metrics need context beyond just improving numbers [50:16] – How screen time and dopamine overload impact energy, libido, and focus [53:08] – The expanding Troscriptions product line and the goal of needing less over time Scott's First Episode: https://open.spotify.com/episode/42vjXWQ9HAFqOd2avJsj6n?si=76da7d2114694e6a   Links & Resources Connect with Dr. Scott Sherr: https://www.instagram.com/drscottsherr/ Buy Troscriptions: https://troscriptions.com/?rfsn=9066612.3f3859&utm_source=refersion&utm_medium=affiliate&utm_campaign=9066612.3f3859 Use Code: BeautifullyBroken Silver Biotics: https://bit.ly/3JnxyDD Use Code: beautifullybroken   CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.