Subclinical Aldosteronism Fuels MACE 09/30/25

Welcome to Cardiology Today – Recorded September 30, 2025. This episode summarizes 5 key cardiology studies on topics like alternative splicing and dialysis. Key takeaway: Subclinical Aldosteronism Fuels MACE. Article Links: Article 1: Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. (Circulation) Article 2: Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. (Circulation) Article 3: Application of the J-CTO Score to Recanalization for In-Stent Chronic Total Occlusions. (The American journal of cardiology) Article 4: Predictors of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing TAVR. (The American journal of cardiology) Article 5: Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent end stage renal disease Patients Undergoing Percutaneous Coronary Intervention. (The American journal of cardiology) Full episode page: https://podcast.explainheart.com/podcast/subclinical-aldosteronism-fuels-mace-09-30-25/ Featured Articles Article 1: Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40631720 Summary: This longitudinal population-based study found that individuals with subclinical primary aldosteronism, a milder form of excessive aldosterone production, had a significantly increased risk of major adverse cardiovascular events. The findings suggest that subclinical primary aldosteronism is an underrecognized contributor to cardiovascular morbidity, emphasizing the need for its detection and management. Article 2: Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41017471 Summary: Leveraging long-read single-nucleus RNA sequencing, this study generated a detailed atlas of splicing isoform heterogeneity across adult human heart cell types and conditions. It identified significant shifts in isoform usage in heart failure, providing a foundational resource for understanding how alternative splicing contributes to cardiac disease at a molecular level. Article 3: Application of the J-CTO Score to Recanalization for In-Stent Chronic Total Occlusions. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022251 Summary: This study evaluated the utility of the J-CTO score in guiding recanalization procedures for in-stent chronic total occlusions, comparing it to de novo chronic total occlusions. The results indicate that while the J-CTO score is a valuable tool for assessing procedural feasibility and predicting guidewire crossing time, its application and predictive accuracy may differ between in-stent and de novo chronic total occlusions. Article 4: Predictors of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing TAVR. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022250 Summary: This registry-based study investigated the incidence, predictors, and clinical impact of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement. The findings highlight specific patient and procedural characteristics associated with a higher likelihood of permanent pacemaker implantation, informing clinical decision-making. Article 5: Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent end stage renal disease Patients Undergoing Percutaneous Coronary Intervention. Journal: The American journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41022249 Summary: This real-world cohort study compared the effectiveness and safety of prasugrel versus ticagrelor in end-stage renal disease patients on dialysis undergoing percutaneous coronary intervention. The study aimed to define optimal P2Y₁₂ inhibition in this high-risk, understudied population. Transcript Today’s date is September 30, 2025. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Subclinical Primary Aldosteronism and Major Adverse Cardiovascular Events: A Longitudinal Population-Based Cohort Study. This longitudinal population-based study found that individuals with subclinical primary aldosteronism, a milder form of excessive aldosterone production, had a significantly increased risk of major adverse cardiovascular events. The findings suggest that subclinical primary aldosteronism is an underrecognized contributor to cardiovascular morbidity, emphasizing the need for its detection and management. Article number two. Single-Cell Splicing Isoform Atlas of the Adult Human Heart and Heart Failure. Leveraging long-read single-nucleus RNA sequencing, this study generated a detailed atlas of splicing isoform heterogeneity across adult human heart cell types and conditions. It identified significant shifts in isoform usage in heart failure, providing a foundational resource for understanding how alternative splicing contributes to cardiac disease at a molecular level. Article number three. Application of the J-CTO Score to Recanalization for In-Stent Chronic Total Occlusions. This study evaluated the utility of the J-CTO score in guiding recanalization procedures for in-stent chronic total occlusions, comparing it to de novo chronic total occlusions. The results indicate that while the J-CTO score is a valuable tool for assessing procedural feasibility and predicting guidewire crossing time, its application and predictive accuracy may differ between in-stent and de novo chronic total occlusions. Article number four. Predictors of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing TAVR. This registry-based study investigated the incidence, predictors, and clinical impact of permanent pacemaker implantation in patients with raphe-type bicuspid aortic valve stenosis undergoing transcatheter aortic valve replacement. The findings highlight specific patient and procedural characteristics associated with a higher likelihood of permanent pacemaker implantation, informing clinical decision-making. Article number five. Comparative Effectiveness of Prasugrel versus Ticagrelor in Dialysis-Dependent end stage renal disease Patients Undergoing Percutaneous Coronary Intervention. This real-world cohort study compared the effectiveness and safety of prasugrel versus ticagrelor in end-stage renal disease patients on dialysis undergoing percutaneous coronary intervention. The study aimed to define optimal P2Y₁₂ inhibition in this high-risk, understudied population. Thank you for listening. Don’t forget to subscribe. Keywords alternative splicing, dialysis, major adverse cardiovascular events, single-cell RNA sequencing, P2Y₁₂ inhibition, percutaneous coronary intervention, permanent pacemaker implantation, transcatheter aortic valve replacement, in-stent restenosis, cardiac disease, end-stage renal disease, prasugrel, registry, cohort study, predictors, isoform atlas, guidewire crossing, ticagrelor, subclinical primary aldosteronism, J-CTO score, bicuspid aortic valve stenosis, cardiovascular risk, chronic total occlusion, heart failure, aldosterone. About Concise summaries of cardiovascular research for professionals. Subscribe • Share • FollowThe post Subclinical Aldosteronism Fuels MACE 09/30/25 first appeared on Cardiology Today.