Sugar Switches: HFpEF's Hidden Code 🧩🫀🧬

from Dr RR Baliga's "Got Knowledge Doc" Podkast · host MasterMedFacts LLC

🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️‍🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism

Episode metadata supplied by the publisher feed · Published Jul 9, 2025

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