TdC 339: Polêmicas da sepse - o retorno (Surviving Sepsis 2026)

O Curso TdC de Atualização vai reunir aulas sobre os temas mais frequentes da clínica médica, organizadas para você aprender o que mudou e transformar novas evidências em melhores decisões à beira do leito ou no consultório. Para ativar a notificação da live de lançamento com direito ao desconto imperdível, é só clicar no link abaixo:https://www.youtube.com/watch?v=i_uiG8cKJ3U Aline Campos e João Mendes convidam João Felipe, residente de medicina intensiva do HCFMUSP, para discutir novamente sobre polêmicas da sepse, dessa vez abordando o novo Surviving Sepsis Campaign de 2026 através de casos clínicos. O tema já foi abordado anteriormente nos episódios #41 e #111. Referências:1. Prescott HC et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Crit Care Med. 2026.2. Mekontso Dessap A et al. European Society of Intensive Care Medicine (ESICM) 2025 clinical practice guideline on fluid therapy in adult critically ill patients: part 2-the volume of resuscitation fluids. Intensive Care Med. 2025.3. Yealy DM et al. Early Care of Adults With Suspected Sepsis in the Emergency Department and Out-of-Hospital Environment: A Consensus-Based Task Force Report. Ann Emerg Med. 2021. 4. Jones BE et al. Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia. JAMA Intern Med. 2020. 5. Bai AD et al. Anaerobic Antibiotic Coverage in Aspiration Pneumonia and the Associated Benefits and Harms: A Retrospective Cohort Study. Chest. 2024. 6. Leung LY et al. Door-to-antibiotic time and mortality in patients with sepsis: Systematic review and meta-analysis. Eur J Intern Med. 2024. 7. Alam N et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018.8. Peake SL et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026. Crit Care Med. 2026.9. Douglas IS et al. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial. Chest. 2020.10. Meyhoff TS et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. N Engl J Med. 2022.11. Shapiro NI et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023.12. Permpikul C et al. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER): A Randomized Trial. Am J Respir Crit Care Med. 2019.13. Russell JA et al. Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock. N Engl J Med. 2008.14. Gordon AC et al. Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial. JAMA. 2016.15. Hajjar LA et al. Vasopressin versus Norepinephrine for the Management of Septic Shock in Cancer Patients: The VANCS II Randomized Clinical Trial. Crit Care Med. 2019.16. Kalimouttou A et al. Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study. JAMA. 2025.17. Mallmann C et al. Reduction of Norepinephrine versus Vasopressin in the Stabilization Phase of Septic Shock: RENOVA Clinical Trial. Med Intensiva (Engl Ed). 2025.18. Jeon K et al. Incidence of Hypotension According to the Discontinuation Order of Vasopressors in the Management of Septic Shock: A Prospective Randomized Trial (DOVSS). Crit Care. 2018.