TdC 348: Hipernatremia

Pedro Magno e Caio Bastos convidam Eduarda Guedes para discutir hipernatremia, um distúrbio hidroeletrolítico comum e desafiador na prática hospitalar. Nesse episódio, abordamos as principais causas, a investigação diagnóstica e o manejo dessa situação clínica. Referências: 1. Yun G, Baek SH, Kim S. Evaluation and management of hypernatremia in adults: clinical perspectives. Korean J Intern Med. 2023. 2. Kitisin N, Raykateeraroj N, Hikasa Y, et al. Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients: impact on mortality, morbidity, and treatment-related side effects. J Crit Care. 2025. 3. Hull A, Reddy A. Salty Despair: An Adolescent's Suicide Attempt through Salt Overdose. Psychopharmacol Bull. 2025. 4. Ofran Y, Lavi D, Opher D, Weiss TA, Elinav E. Fatal voluntary salt intake resulting in the highest ever documented sodium plasma level in adults (255 mmol L-1): a disorder linked to female gender and psychiatric disorders. J Intern Med. 2004. 5. Miller NE, Rushlow D, Stacey SK. Diagnosis and Management of Sodium Disorders: Hyponatremia and Hypernatremia. Am Fam Physician. 2023. 6. Drummond JB, Freitas LGO, Freitas IS, Romanowski RM, Soares BS. Pathophysiology and aetiologies of hypernatremia. Best Pract Res Clin Endocrinol Metab. 2026. 7. Adrogué HJ, Madias NE. Hypernatremia. N Engl J Med. 2000. 8. Chand R, Chand R, Goldfarb DS. Hypernatremia in the intensive care unit. Curr Opin Nephrol Hypertens. 2022. 9. Chauhan K, Pattharanitima P, Patel N, Duffy A, Saha A, Chaudhary K, Debnath N, Van Vleck T, Chan L, Nadkarni GN, Coca SG. Rate of Correction of Hypernatremia and Health Outcomes in Critically Ill Patients. Clin J Am Soc Nephrol. 2019. 10. Ryu JY, Yoon S, Lee J, Baek S, Jo YH, Ko KP, Sim JA, Han J, Kim S, Baek SH. Efficacy and safety of rapid intermittent bolus compared with slow continuous infusion in patients with severe hypernatremia (SALSA II trial): a study protocol for a randomized controlled trial. Kidney Res Clin Pract. 2022.