The brain's "skull drains" are far from passive plumbing.

from Dr RR Baliga's "Got Knowledge Doc" Podkast · host MasterMedFacts LLC

The brain's "skull drains" are far from passive plumbing. In Nature (2026), Monaghan et al. show that dural venous sinuses actively constrict, dilate, and even rearrange endothelial borders in a phenomenon called "ruffling" to support immune surveillance. RAMP1 regulates vasomotion. RAMP2 regulates immune boundary dynamics. Blocking RAMP2 impairs antiviral defense. The meninges are not coverings. They are regulated neuroimmune interfaces. 🧠🛡️

Episode metadata supplied by the publisher feed · Published Feb 20, 2026

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The brain's "skull drains" are far from passive plumbing.

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