🩸 The Dementia Signal in Blood: GDF15 Points to Vascular Risk

🧠 New Science Advances study: plasma growth/differentiation factor-15 (GDF15) measured in midlife and late life predicted long-term dementia risk, with the strongest signal for vascular dementia. The study links GDF15 to cerebral small vessel disease, neurodegeneration, phosphorylated tau, and neuroimmune activation—suggesting this blood biomarker may be more than a bystander. 🩸🔬 Key clinical pearl: dementia prevention may need to look beyond amyloid and focus earlier on vascular–immune biology. #Dementia #GDF15 #Neuroinflammation #VascularDementia #MedicalPodcasts