The Future of CSF Modulation with Pharaoh Neuro

In this episode of The Open Loop, Chay Carter is joined by Dr Nandan Lad and Amaza Reitmeier, the executive leaders behind Pharaoh Neuro.Nandan is a neurosurgeon at Duke and the inventor behind Neurapheresis, while Amaza brings nearly 25 years of leadership experience from Medtronic, including deep experience in brain therapies and DBS.This is a practical conversation about Pharaoh Neuro’s mission to create a new category in brain care: CSF modulation, or what Nandan describes as “neurodialysis”.We explore how Neurapheresis could change the treatment pathway for subarachnoid haemorrhage and hemorrhagic stroke by actively filtering cerebrospinal fluid, removing blood and inflammatory material, and helping reduce devastating downstream complications.We also discuss the company’s clinical data, Series A raise, regulatory pathway, reimbursement strategy, and the broader platform potential across neuroinflammatory conditions.Key takeaways:🔹 Why hemorrhagic stroke remains a major unmet need in brain care🔹 How Neurapheresis works as a closed-loop CSF filtration system🔹 Why Pharaoh Neuro is building a new therapeutic category, not just a device🔹 What early clinical studies showed in blood and protein clearance🔹 How CSF modulation could expand into meningitis, ALS, MS, leptomeningeal disease, and other neuroinflammatory conditionsHost: Chay CarterFounder, Carter Sciences | Co-Founder, Reccy NeuroLinkedIn: https://www.linkedin.com/in/chay-carter/ Guest: Amaza ReitmeierCEO & Director, Pharaoh NeuroLinkedIn: https://www.linkedin.com/in/amaza-reitmeier/ Guest: Nandan LadChief Medical Officer & Co-Founder​LinkedIn: https://www.linkedin.com/in/nandan-lad-6262805/ Key Chapters:00:00 Introduction to Pharaoh Neuro and Its Founders02:39 The Origin Story of Neurapheresis05:27 How Neurapheresis and CSF Modulation Work10:20 Clinical Validation and Early Patient Results13:31 Regulatory Pathways and Creating a New Category15:25 Platform Potential Beyond Hemorrhagic Stroke20:18 Pharaoh Neuro and the Broader Neurotech Landscape23:36 Restoring CSF Balance and What Comes NextThe Open Loop is a podcast exploring the people, companies, and ideas shaping the future of neurotechnology.🔔 Subscribe for weekly conversations with the founders, researchers, and operators building what comes next in brain health, medicine, and technology.