The Key to Weight Loss - How to Optimize Leptin, the Master Fat Hormone

Hormone optimization is essential for maintaining a healthy weight, and one of the most important hormones for fat loss is leptin. Leptin helps our bodies maintain a healthy weight by communicating with the brain when fat mass is accumulating, so that the brain can respond by reducing hunger and increasing energy expenditure. Unfortunately, leptin-resistance can develop, causing our brain to stop responding to leptin appropriately, causing the body to gain more and more fat. In this episode, we will discuss the role of leptin and other hormones in the accumulation and loss of fat, and how to optimize these hormones naturally, without the use of harmful weight loss drugs. Citations Dornbush S, Aeddula NR. Physiology, Leptin. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537038/ https://www.novomedlink.com/diabetes/products/treatments/ozempic/about/mechanism-of-action.html Collins L, Costello RA. Glucagon-Like Peptide-1 Receptor Agonists. [Updated 2023 Jan 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551568/ Müller TD, Finan B, Bloom SR, et al. Glucagon-like peptide 1 (GLP-1). Mol Metab. 2019;30:72-130. doi:10.1016/j.molmet.2019.09.010 Hira T, Trakooncharoenvit A, Taguchi H, Hara H. Improvement of Glucose Tolerance by Food Factors Having Glucagon-Like Peptide-1 Releasing Activity. Int J Mol Sci. 2021;22(12):6623. Published 2021 Jun 21. doi:10.3390/ijms22126623 6. Anand David AV, Arulmoli R, Parasuraman S. Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid. Pharmacogn Rev. 2016;10(20):84-89. doi:10.4103/0973-7847.194044