The Problem with Senolytics That Clinical Trials Missed | Dr Sundeep Khosla

Mayo Clinic's Dr. Sundeep Khosler discusses findings from the first major randomized controlled trial of senolytics in humans, revealing why cellular aging varies dramatically between individuals and what this means for longevity interventions.Dr. Sundeep Khosler, a physician-researcher at the Mayo Clinic, leads some of the first human clinical trials testing senolytics for aging and age-related diseases. In this conversation, he shares critical findings from their 60-person randomized controlled trial that challenge assumptions about how we age at the cellular level.The study revealed that senescent cell burden varies dramatically between individuals, with significant implications for who might benefit from senolytic interventions. While overall results showed modest improvements in bone formation markers, women with the highest senescent cell burden (measured through blood biomarkers) showed dramatic 60% improvements—suggesting aging interventions may require personalized approaches rather than universal protocols.Dr. Khosler discusses the development of blood-based biomarkers for measuring senescent cell burden, explains why age 70 appears to be a critical threshold, and addresses the gap between promising animal studies and human translation. He provides evidence-based guidance on what people can do now, explains why he doesn't recommend current senolytics outside clinical trials, and discusses FDA-approved medications that may impact cellular aging as secondary benefits.This interview offers a balanced, nuanced perspective on where senolytic research actually stands, moving beyond hype to understand both the promise and limitations of targeting senescent cells for healthspan.🌐Links in this video Dr Khosla's page at the Mayo Clinic https://www.mayo.edu/research/faculty/khosla-sundeep-m-d/bio-00078126Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trialhttps://pubmed.ncbi.nlm.nih.gov/38956196/Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan